子宫内膜异位症不孕患者血清泌乳素水平分析

Analysis of serum prolactin level in patients with endometriosis and infertility

目的:探讨子宫内膜异位症不孕患者与非子宫内膜异位症不孕患者血清卵泡刺激素、黄体生成素、雌二醇、睾酮、促甲状腺激素及泌乳素的差异。方法:选取2015~2016年907例子宫内膜异位症不孕患者(观察组),与1579例非子宫内膜异位症的不孕患者(对照组),对比分析两组患者激素水平。结果:两组卵泡刺激素、黄体生成素、雌二醇、睾酮、促甲状腺激素水平差异无统计学意义。观察组泌乳素水平[(17.8±8.8)ng/mL vs.(16.8±8.2)ng/mL]高于对照组,差异有统计学意义(P=0.005)。子宫内膜异位症卵巢型患者血清泌乳素水平为(17.1±7.1)ng/mL,腹膜型为(18.9±11.0)ng/mL,腹膜型高于卵巢型,差异有统计学意义(P=0.009)。结论:子宫内膜异位症不孕患者泌乳素水平升高,针对泌乳素的机制研究与干预可能有助于了解不孕症的发生机制、提高临床诊治效果。

Objective:To investigate the difference of serum follicle stimulating hormone,luteinizing hormone,estradiol,testosterone,thyroid stimulating hormone and prolactin between infertile patients with endometriosis and those without endometriosis.Methods:From 2015 to 2016,907 infertile patients with endometriosis(observation group)and 1579 infertile patients without endometriosis(control group)were selected,and the hormone levels of the two groups were analyzed.Results:There was no significant difference in the levels of follicle stimulating hormone,luteinizing hormone,estradiol,testosterone or thyroid stimulating hormone between the two groups.The prolactin level in observation group was higher than that in the control group[(17.8±8.8)ng/mL vs.(16.8±8.2)ng/mL,P=0.005].The serum level of prolactin was(17.1±7.1)ng/mL in ovarian type endometriosis patients and(18.9±11.0)ng/mL in peritoneal type patients.The prolactin level in peritoneal type patients was higher than that in ovarian type patients,and the difference was statistically significant(P=0.009).Conclusions:The level of prolactin in infertile patients with endometriosis is increased.The mechanism research and intervention of prolactin may help to understand the mechanism of infertility,improving the effect of clinical diagnosis and treatment.