粤东地区19178例宫颈样本HPV分型及其与宫颈病变的关系

Relationship between human papilloma virus genotyping in 19178 cervical samples and cervical lesions in the eastern Guangdong

目的了解粤东地区生殖道HPV分型及其与宫颈病变的关系。方法 19 178例宫颈样本作HPV分型检测,其中8 399例进行阴道脱落细胞液基细胞学检查,分析HPV亚型与宫颈病变的关系。结果 HPV阳性感染率为16.94%,其中高危型、低危型HPV分别占81.55%、18.45%;最常见高危与低危亚型分别是HPV52(16.78%)、HPV6(5.81%)。≥61岁组的总感染率、单一基因及单纯高危亚型感染率均高于21~60岁年龄段(P<0.01);癌变组HPV阳性率和高危型感染率明显高于非典型鳞状上皮细胞组和宫颈正常组(P<0.05)。结论粤东地区女性HPV感染以单一基因和高危亚型感染为主;随着宫颈病变程度增加,高危型HPV感染率逐渐升高。

Objective To investigate the relationship between human papilloma virus(HPV) genotyping in genital tract and cervical lesions in the eastern Guangdong. Methods HPV genotyping was performed in 19 178 cervical samples, 8 399 of which were subjected to liquid-based cytology. The relationship between HPV subtypes and cervical lesions was analyzed. Results The overall HPV positive rate was 16.94%, and high-and low-risk types accounted for 81.55% and 18.45%, respectively. The most common high-and low-risk subtypes were HPV52(16.78%) and HPV6(5.81%), respectively. The total infection rate, single subtype and simple high-risk subtype infection rates were higher in women aged ≥61 years than in 21-60 years(P<0.01). HPV positive rate and high-risk subtype infection in cancerous group were increased compared with atypical squamous cells-undetermined significance(ASC-US) and normal cervical group(P<0.01). Conclusion Cervical infection of single and high-risk HPV subtypes in women is common in the eastern Guangdong. High-risk HPV subtype infection is incremental with the aggravation of cervical lesions.