反复呼吸道感染儿童血清微量元素水平与IL-6、IL-17的关系分析

The relationship between serum trace elements and IL-6,IL-17 in children with recurrent respiratory tract infection

目的分析反复呼吸道感染(RRTI)儿童的全血微量元素水平与IL-6、IL-17的关系。方法测定78名RRTI患儿的血清微量元素和IL-6、IL-17水平,并以IL-17、IL-6水平的中位值为界,将RRTI患儿分为IL-17和IL-6高、低两组,通过逐步多元线性回归分析RRTI患儿血清微量元素与IL-6、IL-17的关系。结果 IL-17高组患儿的铬(Cr)和钒(V)水平明显高于IL-17低组(P<0.05),IL-6高组的Cu水平明显高于IL-6低组(P<0.05)。相关分析显示,血清Cr、V水平与IL-17呈正相关,Mg、Fe水平与IL-17呈负相关(P<0.05);Cu、Cr与镉(Cd)水平与IL-6呈正相关,Fe水平与呈IL-6负相关(P<0.05)。结论 RRTI儿童中血清Mg、Cr、Fe、V、Cd、Cu水平的改变与炎症发生直接相关。

Objective To analyze the relationship between serum trace element levels and IL-6 and IL-17 in children with recurrent respiratory tract infection(RRTI).Methods The serum trace element levels and IL-6 and IL-17 of 78 children with RRTI were measured.The RRTI children were divided into the high and low IL-16 and IL-17 groups according to the median of IL-16 and IL-17.Stepwise multiple linear regression analysis was conducted to analyze the relationship between serum trace element levels and IL-6 and IL-17 in RRTI children.Results The High IL-17 Group had the Cr andV level significantly higher than the Low IL-17 Group(P<0.05),and the High IL-16 Group had the Cu level significantly higher than the Low IL-16 Group(P<0.05).Correlation analysis showed that the serum Cr andV levels were positively correlated with the IL-17 level(P<0.05),and the serum Mg and Fe levels were negatively correlated with the IL-17 level(P<0.05).The Cr and Cd levels were positively correlated with the IL-16 level and the Fe level was negatively related to the IL-16 level(P<0.05).Conclusion The changes of serum levels of trace elements including Mg,Cr,Fe,V,Cd and Cu are directly correlated with the inflammation in RRTI children.