新生儿呼吸窘迫综合征患儿血清CTRP3表达及其与TNF-α、IL-6相关性

Serum CTRP3 level and its correlation with TNF-α and IL-6 in neonatal respiratory distress syndrome

目的观察新生儿呼吸窘迫综合征(NRDS)患儿血清CTRP3水平及其与肿瘤坏死因子α(TNF-α)、白介素6(IL-6)相关性。方法采用酶联免疫吸附法(ELISA)检测75例NRDS患儿(轻度48例、中重度27例)、40例非NRDS早产儿(对照组)CTRP3、TNF-α和IL-6水平,并分析其相关性。结果治疗前中重度NRDS组患儿血清TNF-α和IL-6水平明显高于对照组和轻度NRDS组,CTRP3水平则降低(P<0.01)。治疗后NRDS患儿血清CTRP3、TNF-α、IL-6均恢复至正常水平。NRDS患儿血清CTRP3与TNF-α、IL-6水平呈负相关(r=-0.245,P<0.05;r=-0.334,P<0.01)。结论血清CTRP3水平似可用于预测NRDS病情严重程度。

Objective To study serum CTRP3 level and its correlation with tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in neonatal respiratory distress syndrome(NRDS).Methods Serum levels of CTRP3,TNF-αand IL-6 and their correlation were determined by ELISA in 75 NRDS cases(mild,n=48;moderate-severe,n=27)and 40 NRDS-free preterm infants(control group).Results Compared with mild NRDS and control groups,serum TNF-αand IL-6 levels were higher,while CTRP3 content was lower in moderate-severe NRDS group before therapy(P<0.01).Their levels returned to normal range in NRDS group after therapy.CTRP3 level was negatively correlated with TNF-α(r=-0.245,P<0.05)and IL-6 levels(r=-0.334,P<0.01)in NRDS group.Conclusion Serum CTRP3 level might predict the severity of NRDS.