系统性红斑狼疮患者血清25羟基维生素D3的表达及其与自身抗体的关系

Expression of serum 25-hydroxy vitamin D3 in patients with systemic lupus erythematosus and its relationship with autoantibody

目的探讨系统性红斑狼疮(SLE)患者血清25羟基维生素D3[25-(OH)D3]水平的表达及其与自身抗体间的关系。方法选取SLE患者80例,根据SLE疾病活动度评分(SLEDAI)分为SLE活动期组(32例,SLEDAI≥10分)和SLE稳定期组(48例,SLEDAI<10分),同时收集同期体检健康者80例作为对照组。抽取试验组与对照组患者空腹静脉血3mL进行25-(OH)D3及自身抗体检测。结果 SLE活动期组和SLE稳定期组患者的血清25-(OH)D3水平均低于对照组,且SLE活动期组降低更显著,其血清25-(OH)D3缺乏的患者最多,其次是SLE稳定期组(P<0.01)。ANA高滴度组患者的血清25(OH)D3水平显著低于中滴度组和低滴度组(P<0.01);抗双链DNA抗体、抗核小体抗体、抗组蛋白抗体阳性患者的25-(OH)D3水平与阴性患者比较差异有统计学意义(P<0.05或0.01)。结论 SLE患者普遍缺乏维生素D;25-(OH)D3的表达及其与患者抗体的关系可能与SLE的病变过程有关。

Objective To explore the expression of serum 25-hydroxy vitamin D3[25-(OH)D3] level in patients with systemic lupus erythematosus(SLE) and its relationship with their autoantibody. Methods A total of 80 SLE patients who were selected as the research subjects and divided into the SLE Active Group(32 cases with the SLEDAI≥10 points) and SLE Stable Group(48 cases with the SLEDAI<10 points) according to SLEDAI. At the same time, 80 healthy people who underwent physical examination during the same period were selected as the Control Group. 3 ml of fasting venous blood was collected from the experimental groups and the Control Group for the determination of 25-(OH)D3 and autoantibody. Results The serum 25-(OH)D3 level in the SLE Active Group and the SLE Stable Group was all significantly lower than that in the Control Group, and the SLE Active Group showed a more significant change and had the most patients with serum 25-(OH)D3 deficiency, followed by the SLE Stable Group(P<0.01). The ANA High Titer Group had the serum 25-(OH)D3 level significantly lower than the ANA Intermediate Titer Group and the ANA low Titer Group(P<0.01). There was statistical difference in the serum 25-(OH)D3 level between the patients with anti-double-stranded DNA antibody, anti-nucleosome antibody and anti-histone antibody positive and those negative(P<0.05 or 0.01). Conclusion SLE Patients are generally deficient in vitamin D. The expression of 25-(OH)D3 and its relationship with the patient antibody may possibly be related to the disease activity of SLE patients.