胆道菌群与胆管癌关系的研究进展

Research progress on the relationship between biliary flora and cholangiocarcinoma

目的总结胆道菌群与胆管癌关系的研究进展。方法收集关于胆道菌群与胆管癌关系的相关文献并进行综述。结果胆道菌群与胆道疾病的发生发展密切相关,胆道的炎症环境是胆管癌发生发展的重要因素,微生物可能通过诱发宿主组织的慢性炎症,导致细胞增殖以及遗传突变,并最终导致胆管癌发生。细菌感染可能在胆管癌的发病机制中起重要作用。结论研究胆道菌群在胆管癌发生发展中的作用,可能为胆管癌的预防及治疗策略开拓新的方向。

Objective To summarize the research progress of the relationship between biliary flora and cholangiocarcinoma.Method The literatures on the relationship between biliary flora and cholangiocarcinoma were collected and reviewed.Results Biliary flora was closely related to the occurrence and development of biliary tract diseases.The inflammatory environment of the biliary tract was an important factor in the occurrence and development of cholangiocarcinoma.Microbes might induce chronic inflammation of the host tissue,leading to cell proliferation and genetic mutation,and ultimately leading to the occurrence of cholangiocarcinoma.Bacterial infection might play an important role in the pathogenesis of cholangiocarcinoma.Conclusion The study of the role of biliary flora in the development of cholangiocarcinoma may open up a new direction for the prevention and treatment of cholangiocarcinoma.