双歧三联活菌联合熊去氧胆酸对肝硬化患者的肝功能及血清降钙素原水平的影响

Effect of bifid triple viable bacteria combined with ursodeoxycholic acid on liver function and serum procalcitonin level in patients with liver cirrhosis

目的:观察双歧三联活菌联合熊去氧胆酸对肝硬化患者的肝功能及血清降钙素原水平的影响。方法:58例肝硬化患者,按照随机数字表法分为观察组(n=30)和对照组(n=28),2组在常规治疗基础上,对照组采用双歧三联活菌(3粒,2次/d)治疗,观察组采用双歧三联活菌联合熊去氧胆酸(250 mg,3次/d)治疗。1个月后观察2组治疗疗效、治疗前后肝功能、凝血功能,Child-Pugh评分、降钙素原(PCT)水平。结果:治疗后,观察组总有效率显著高于对照组(P<0.01);ALT、AST、TBil、I-Bil、DBIL水平均显著低于对照组(P<0.01);PTA显著高于对照组(P<0.01);PT、APTT水平显著低于对照组(P<0.01);Child-Pugh评分、PCT水平显著低于对照组(P<0.01)。结论:双歧三联活菌联合熊去氧胆酸可有效改善肝硬化患者的临床症状,可降低血清PCT水平,降低血生化值,改善肝功能和凝血功能。

Objective: To observe the effect of Bifid Triple Viable Bacteria combined with ursodeoxycholic acid on liver function and serum procalcitonin level in patients with liver cirrhosis. Methods: Fifty-eight cases of Cirrhosis. According to random number table, those patients were divided into the observation group(n=30) and the control group(n=28). On the basis of routine treatment, The control group was treated with Bifid Triple Viable Bacteria(3 capsules, twice a day), while the observation group treated with Bifid Triple Viable Bacteria combined with ursodeoxycholic acid(250 mg, 3 times a day). One month later, the therapeutic effect, liver function, coagulation function, Child-Pugh score and procalcitonin(PCT) level of the two groups were observed before and after treatment. Results: After treatment, The total remission rate in the observation group was significantly higher the control group(P<0.05). The levels of ALT, AST, TBil, I-Bil, DBIL were significantly lower than the control group(P<0.01). PTA was significantly higher than the control group(P<0.01). The levels of PT and APTT were significantly lower than the control group(P<0.01). Child-Pugh score and PCT levels were significantly lower than the control group(P<0.01). Conclusion: Bifid Triple Viable Bacteria combined with ursodeoxycholic acid can effectively improve the clinical symptoms of patients with liver cirrhosis, reduce serum procalcitonin level, reduce blood biochemical value, improve liver function and coagulation function.