基于中国生物医学文献数据库的宫颈癌治疗相关文献可视化分析

Visualized analysis of literature on the treatment of cervical cancer in Chinese biomedical literature database

目的:利用可视化方法分析我国宫颈癌治疗的研究现状和热点,为宫颈癌治疗提供参考依据。方法:应用计算机检索中国生物医学文献数据库(China biology medicine disc,CBMdisc)2001-01-01~2019-11-01以中文形式全文发表的宫颈癌治疗的相关文献,运用书目共现分析系统-2(bibliographic items co-occurrence matrix builder 2,BICOMS 2)对文献进行提取和整理,利用NetDraw和图形聚类工具包(graphical clustering toolkit,Gcluto)绘制网络关系图并进行聚类分析。结果:共检索宫颈癌治疗相关文献2141篇,最终纳入文献2089篇。发文量分析显示,2001~2019年发文量呈阶梯式上升,主要研究机构以医科类大学为主;2001~2019年累计发文量≥10篇的院所7家,其中≥15篇的院所3家,≥20篇的院所仅1家;载文量>40篇的期刊仅1本;参与相关文献撰写的作者共5648人,但发文量>5篇的作者不多,且未见跨省市院所之间的合作关系。对出现频次>8次的96个高频主题词进行社会网络分析显示,宫颈癌治疗研究主要围绕“宫颈癌”展开,新辅助化疗、放疗、化疗和手术治疗是目前宫颈癌治疗的研究热点,低频电刺激、腔内后装放疗、PD-1和PD-L1等也有广泛研究。对96个高频主题词进行聚类分析显示,目前宫颈癌治疗研究热点主要集中在7个主题,即:①尿潴留,特别是宫颈癌术后,易影响膀胱功能;②PD-1和PD-L1对宫颈癌细胞凋亡的影响;③晚期宫颈癌化疗药物的选择;④通过联合放化疗、辅助支持治疗,早中期宫颈癌的临床疗效和预后;⑤年轻宫颈癌患者应尽可能保留生育功能;⑥根治性手术治疗以及联合动静脉全身化疗是治疗巨快型宫颈癌的关键;⑦通过手术治疗、联合放化疗及综合护理干预宫颈癌的临床疗效和预后。结论:近年来开展宫颈癌治疗研究的单位众多,但跨院所之间的资源共享和学术交流仍不足,需加强各机构间合作,提高和扩大宫颈癌临床诊疗、免疫治疗及综合护理的研究质量和规模。

Objective:To analyze the current situation and hotspot of cervical cancer treatment in China by visualization approach,and to provide a reference for further research in this field.Methods:The literatures related to the treatment of cervical cancer published in Chinese in the China biology medicine disc(CBMdisc)from January 2001 to November 2019 were selected by computer,and they were extracted and sorted by bibliographic items co-occurrence matrix builders-2(BICOMS 2)software.NetDraw was used to draw social relation diagrams,and the cluster analysis keywords was conducted by graphical clustering toolkit(Gcluto).Results:A total of 2141 literatures on cervical cancer treatment were retrieved,and a total of 2089 literatures were included in visual analysis.Publications volume analysis showed that the number of publications from 2001 to 2019 rose in a stepped manner.The major research institutions were medical universities.From 2001 to 2019,7 institutions published more than 10 literatures,among which 3 institutions with more than 15 literatures,and only one institution with more than 20 literatures.There were only one journal with more than 40 articles.A total of 5648 author wrote related literatures,but there were few authors with more than 5 literatures published,and no inter-provincial cooperation was found.A social network analysis of 96 high-frequency major keywords that appeared more than 8 times showed that the study of cervical cancer treatment mainly focused on"cervical cancer".Neoadjuvant chemotherapy,radiotherapy,chemotherapy and surgical treatment were current research hospital of cervical cancer,and low-frequency electrical stimulation,intracavitary radiotherapy,PD-1 and PD-L1 were also widely studied.The result of cluster analysis of 96 high-frequency subject words showed that cervical cancer treatment mainly focused on seven topics,namely:①Urinary retention,especially after cervical cancer surgery,easily affects bladder function.②Effects of PD-1 and PD-L1 on apoptosis of cervical cancer cells.③Selection of chemotherapy drugs for advanced cervical cancer.④Clinical efficacy and prognosis of early and middle stage cervical cancer through combined chemoradiotherapy and auxiliary supportive treatment.⑤Young cervical cancer patients should preserve their fertility function as far as possible.⑥Radical surgical treatment and systemic arteriovenous chemotherapy are key to the treatment of hyperrapid cervical cancer.⑦Clinical efficacy and prognosis of cervical cancer intervention through surgery,combined chemoradiotherapy and comprehensive nursing care.Conclusion:In recent years,many units carry out research on the treatment of cervical cancer,but the resource sharing and academic exchange among institutions are still insufficient.Therefore,inter-institutional cooperation should be strengthened to improve and expand the research quality and scale of clinical diagnosis and treatment,immunotherapy and comprehensive nursing of cervical cancer.