固定无偿献血者血清铁和血清铁蛋白的变化研究

Changes of serum iron and ferritin in regular voluntary blood donors

目的了解固定献血者定期献血对其体内血清铁、血清铁蛋白等水平影响。方法从2019年1月~2019年6月在本中心参加献血的固定献血者当中随机抽取240人(份)的血样[(4~5 mL/人(份)),EDTA-2K抗凝管]作为研究组,同时随机抽取200名正常值范围内的体检人员作为对照组;分别采用Ferene法测定2组受检者的血清铁(SI),化学发光测定血清铁蛋白(SF),以及鞘液电阻法测定血常规等各项指标。结果研究组与对照组受检者的血红蛋白、红细胞计数、血细胞比容等血常规指标均处于正常值范围;SI(mol/L)为17.13±4.36 vs 17.82±5.78(P>0.05),SF(ng/mL)为98.34±52.74 vs 147.52±91.52(P<0.05)。结论固定无偿献血在一定程度上会降低献血者的血清铁和血清铁蛋白水平;因此在统筹献血活动时需密切随访以上指标,保障固定献血者安全。

Objective To study the effect of regular blood donation on the serum iron(SI) and serum ferritin(SF) of regular blood donors. Methods A total of 240 blood samples(4~5 mL per person, with EDTA-2 K anticoagulant) from regular voluntary blood donors in our center from January to June 2019 were randomly selected as the study group. Another 200 healthy subjects without blood donation history were randomly selected as the control group. SI was measured by Ferene method, SF by chemiluminescence method, and blood routine indexes by automatic hematology analyzer. Results The Hb, RBC count, HCT and other blood routine indexes of the study group and the control group were all in the normal range. SI(mol/L) in the study gourp and the control group was 17.13±4.36 vs 17.82±5.78(P>0.05), and SF(ng/mL) was 98.34±52.74 vs 147.52±91.52(P<0.05). Conclusion SI and SF may decrease due to regular blood donation, which deserve close follow-up to ensure the safety of regular blood donors.