多次捐献单采血小板固定献血者外周血常规的变化

Impact of multiple platelets donation on peripheral blood routine in regular blood donors

目的探讨多次频繁捐献单采血小板后献血者外周血常规的变化情况。方法选择228名自愿捐献单采血小板次数≥5次的献血者,统计首次和末次采集血小板前外周血常规的检测结果,分别从献血量,献血频次(总次数/总月数),献血次数3方面分组分析数据。结果 1)WBC在累计血小板献血量>18治疗量,献血次数>10次开始WBC计数减少差异具有统计学意义(P<0.05);2)RBC在自身代偿后当献血量≥36治疗量、献血频率≥1.4、献血次数>18次,RBC计数减少差异具有统计学意义(P<0.05);3)Hb在献血量>18治疗量、献血频率≥1、献血次数>18次时Hb计数减少差异具有统计学意义(P<0.05);4)Plt在献血量>18治疗量时,末次计数值即明显高于首次计数(P<0.05),而当献血量继续增加时,虽然末次计数值高于首次计数,但无统计学意义(P>0.05),当献血量达到≥76治疗量时,末次计数值再次明显高于首次计数(P<0.05)。Plt在献血频率>1.4,献血次数≥40次时,末次计数值明显高于首次计数(P<0.05)。结论多次频繁单采血小板的采集使献血者外周血的各项指标有不同程度的改变,但仍在正常范围内波动。当献血者Plt捐献量>18,频率>1.4,次数>18次时,建议可以适当延长献血者间隔时间和(或)补充铁剂。

Objective To investigate the changes in peripheral blood routine in blood donors after multiple and frequent platelets donation. Methods A total of 228 voluntary blood donors who donated apheresis platelets for 5 or more times were selected. The results of peripheral blood routine testing before the first and most recent donation were collected. The data were analyzed in terms of blood donation volume, frequency of blood donation(total frequency/total months), and numbers of blood donation.Results 1) There was statistical significance in the decrease of WBC counts when the accumulative volume of platelet donation >18 treatment doses and the number of blood donation >10(P<0.05). 2) After self-compensating, the difference in RBC counts decrease was statistically significant as blood donation volume ≥36 treatment doses, blood donation frequency ≥1.4, and number of blood donation >18,(P<0.05). 3) There was statistical significance in the decrease of Hb when blood donation volume >18 treatment doses, blood donation frequency ≥1, and the number of blood donation >18(P<0.05). 4) The Plt value of most recent donation was significantly higher than the first one when blood donation volume was >18 treatment doses(P<0.05), then the gaps in Plt values shrank to marginal as the donation continued(P>0.05), and a significant lead in the Plt value of most recent donation was observed again until the blood donation volume reached ≥76 treatment doses(P<0.05). When the frequency of blood donation was >1.4 and the number of blood donations≥40, the Plt value of the most recent donation was significantly higher than that of the first one(P<0.05). Conclusion The indexes of peripheral blood in multiple donors were found to be fluctuating due to the frequent platelet donation, but still within the normal range. When platelet donation volume>18 treatment doses, blood donation frequency >1.4, and the number of donation >18, it is recommended to extend the donation interval and/or take iron supplements appropriately.