Hp感染与服用抗血小板药物的老年患者上消化道出血的临床研究

Clinical study on Hp infection and upper gastrointestinal bleeding in elderly patients taking antiplatelet agents

目的研究幽门螺杆菌(Hp)感染与服用抗血小板药物的老年患者上消化道出血(UGIB)关系。方法选择220例服用抗血小板药物的老年患者按是否发生UGIB分组,设UGIB组及非UGIB组,分析口服抗血小板药物的老年患者发生UGIB的危险因素。结果Hp感染、血肌酐(SCr)>115~442μmol/L、双抗血小板方案均是服用抗血小板药物老年患者上消化道出血的独立危险因素。结论应重视服用抗血小板药物老年患者的Hp感染情况,积极根除Hp感染、合理应用胃肠黏膜保护剂以降低UGIB风险。

Objective To study the relationship between helicobacter pylori(Hp)infection and upper gastrointestinal hemorrhage(UGIB)in elderly patients taking antiplatelet agents.Methods 220 elderly patients taking antiplatelet drugs were divided into UGIB group and non-UGIB group according to whether they had UGIB,and the risk factors of UGIB were analyzed in elderly patients taking antiplatelet drugs orally.Results Hp infection,serum creatinine(SCr)>115-442 mol/L and dual antiplatelet regimen were independent risk factors for upper gastrointestinal bleeding in elderly patients taking antiplatelet drugs.Conclusion Attention should be paid to Hp infection in elderly patients taking antiplatelet drugs,Hp infection should be eradicated actively and gastrointestinal mucosal protective agents should be used reasonably to reduce the risk of UGIB.