医学原虫相关蛋白的免疫调节作用研究进展

Research progress on immune regulation of medical protozoa-related proteins

原虫是一类结构简单的单细胞真核生物,种类繁多,广泛分布于自然界。医学原虫可以寄生于人体的体液、组织或细胞等,通过多种有效机制调节宿主的免疫应答,逃避宿主免疫系统的攻击,使虫体在宿主体内生存繁殖并引起疾病。本文就疟原虫、刚地弓形虫、杜氏利什曼原虫和蓝氏贾第鞭毛虫相关蛋白的免疫调节作用进行综述,以期为防治医学原虫相关的寄生虫病提供资料。

Protozoan, a type of single-celled eukaryotes with simple structure, is widely distributed in natural world. Medical protozoa can parasitize humans in body fluid, tissues and cells, and regulate host immune response,escaping from attack of the host immune system, and enabling survival and proliferation in the host and causing the occurrence of disease. In this paper, we summarize the immunomodulatory effects of proteins associated with Plasmodium, Toxoplasma gondii, Leishmania donovani and Giardia lamblia, in order to provide information for the prevention and treatment of medical protozoa-related parasitic diseases.