FcγR基因多态性与牙周炎易感性的Meta分析

Fcγreceptor polymorphisms contribute to periodontitis susceptibility:a meta-analysis

目的探讨FcγRⅡa、FcγⅢa和FcγRⅢb的基因多态性与牙周炎发病风险性的相关性。方法通过检索PubMed、Web of Science、中国知网和万方等中英文数据库,纳入2019年10月前所有符合纳入标准的有关FcγRⅡa、FcγⅢa和FcγRⅢb的基因多态性与牙周炎发病风险性的研究,共27项病例对照研究,其中包含2105个病例和1115个对照,采用RevMan 5.3软件进行Meta分析,利用优势比(OR)及95%置信区间(CI)评价效应强度。结果Meta分析结果合并显示FcγRⅡa和FcγRⅢb的基因多态性与牙周炎的发病风险无显著相关性,但FcγⅢa的基因多态性可能增加慢性牙周炎发病风险(V vs.F,OR=1.93,95%CI 1.01~3.69)。根据种群进行亚组分析,FcγRⅡa H131R位点的突变型可能会增加亚洲人群慢性或侵袭性牙周炎的发病风险[慢性牙周炎:R vs.H,OR=1.22,95%CI 1.04~1.42,(HR+RR)vs.HH,OR=1.28,95%CI 1.03~1.59;侵袭性牙周炎:R vs.H,OR=1.60,95%CI 1.01~2.54],但可能会降低高加索人群慢性牙周炎的发病风险[(HR+RR)vs.HH,OR=0.66,95%CI 0.48~0.90]。FcγⅢa F158V位点的突变型可能增加高加索人群慢性牙周炎的发病风险[V vs.F,OR=1.73,95%CI 1.06~2.85,(VV+FV)vs.FF,OR=2.26,95%CI 1.06~4.82]。FcγRⅢb NA1/NA2位点的NA2等位基因可能会降低包含50%高加索人群的混合人群侵袭性牙周炎的发病风险[(NA1NA2+NA2NA2)vs.NA1NA1,OR=0.57,95%CI 0.34~0.94]。结论FcγRⅡa、FcγⅢa和FcγRⅢb的基因多态性与牙周炎发病风险性之间的联系可能存在着种族差异,需要更大样本、更高质量的研究来进一步证实。

Objective To explore the associations between Fcγreceptor(FcγR)polymorphisms and periodontitis.Methods We searched electronic databases,including PubMed,Web of Science,CNKI,WanFang and other Chinese-English databases,and relevant research published through October 2019.Twenty-seven case-control studies involving 2105 cases and 1115 controls on FcγR polymorphisms and periodontitis were retrieved and analyzed.RevMan 5.3 software was used to conduct the meta-analysis.Odds ratios(OR)with the corresponding 95%confidence interval(95%CI)were adopted.Results Pooled results indicated that no significant associations were found between periodontitis and the polymorphisms of FcγRⅡa and FcγRⅢb.However,FcγⅢa polymorphism increased the risk of chronic periodontitis(V vs.F OR=1.93,95%CI 1.01-3.69).In subgroup analysis by ethnicity,the results showed a significant association of FcγRⅡa H131 R polymorphisms with increased risk of chronic or aggressive periodontitis in Asian population(chronic periodontitis:R vs.H OR=1.22,95%CI 1.04-1.42,HR+RR vs.HH OR=1.28,95%CI 1.03-1.59;aggressive periodontitis:R vs.H OR=1.60,95%CI 1.01-2.54),while the associations were not obvious in Caucasian population(RH+RR vs.HH OR=0.66,95%CI 0.48-0.90).FcγⅢa F158 V polymorphism increased the risk of chronic periodontitis in Caucasian population(V vs.F OR=1.73,95%CI 1.06-2.85,VV+FV vs.FF OR=2.26,95%CI 1.06-4.82).The NA2 allele of the FcγRⅢb NA1/NA2 locus reduced the risk of aggressive periodontitis in a mixed population including 50%Caucasians(NA1 NA2+NA2 NA2 vs.NA1 NA1 OR=0.57,95%CI 0.34-0.94).Conclusion There might be ethnic differences in the association of the genetic polymorphisms of FcγRⅡa,FcγⅢa,and FcγRⅢb with periodontitis susceptibility.But high quality studies with larger samples are needed in order to confirm the hypothesis.