体外冲击波联合美洛昔康片对老年骨关节炎患者关节功能及血清MMP-9、抵抗素水平的影响

Effect of extracorporeal shock wave combined with meloxicam tablets on joint function and serum levels of MMP-9 and resistin in elderly patients with osteoarthritis

目的探究体外冲击波联合美洛昔康片对老年骨关节炎患者关节功能及血清基质金属蛋白酶-9(MMP-9)、抵抗素水平的影响。方法选取2016年5月至2019年3月南充市中心医院收治的老年骨关节炎患者80例作为研究对象,进行前瞻性研究,盲法随机分组,各40例。对照组予以常规口服药物(美洛昔康+硫酸氨基葡萄糖钾片)治疗,观察组予以美洛昔康片联合体外冲击波治疗。治疗8周后,统计分析两组治疗总有效率、不良反应发生率,并对比治疗前、疗程结束后骨关节炎症状(WOMCA)、关节功能(Lysholm)评分及血清MMP-9、抵抗素水平。结果观察组疗程结束后WOMCA评分低于对照组,Lysholm评分高于对照组(P<0.05);两组治疗总有效率对比,观察组(95.00%)高于对照组(77.50%)(P<0.05);观察组疗程结束后血清抵抗素、MMP-9水平低于对照组(P<0.05);观察组不良反应发生率(15.00%)与对照组(17.50%)比较差异无统计学意义(P>0.05)。结论体外冲击波联合美洛昔康片治疗老年骨关节炎患者,可显著改善患者临床症状,促进关节功能恢复,降低血清抵抗素、MMP-9水平,进一步提高治疗效果,且安全性高。

Objective To explore the effect of extracorporeal shock wave combined with meloxicam tablets on joint function and serum matrix metalloproteinase-9(MMP-9)and resistin levels in elderly patients with osteoarthritis.Methods 80 cases of elderly patients with osteoarthritis in Nanchong Central Hospital from May 2016 to March 2019 were selected as the research objects,and they were randomly divided into two groups,40 cases in each group.The control group was given conventional oral medicine(meloxicam+potassium glucosamine sulfate tablets),and the observation group was given meloxicam tablets combined with extracorporeal shock wave therapy.The total effective rate,incidence of adverse reactions,and the scores of osteoarthritis symptoms(WOMCA),joint function(Lysholm),serum MMP-9 and resistin before and after 8 weeks'treatment were compared between the two groups.Results After treatment,the WOMCA score of the observation group was lower than that of the control group,and Lysholm score was higher than that of the control group(P<0.05);the total effective rate of the observation group(95.00%)was higher than of the control group(77.50%)(P<0.05);the serum resistin and MMP-9 levels of the observation group were lower than those of the control group after treatment(P<0.05);there was no significant difference in the incidence of adverse reactions between the observation group(15.00%)and the control group(17.50%)(P>0.05).Conclusions Extracorporeal shock wave combined with meloxicam tablets in the treatment of elderly patients with osteoarthritis can significantly improve the clinical symptoms,promote the recovery of joint function,reduce the levels of serum resistin and MMP-9,and further improve the treatment effect with high safety.