基于多孔介质模型的血流导向装置栓塞颅内动脉瘤的敏感性

Sensitivity Analysis of Flow Diverter Treatment of Intracranial Aneurysm Using Porous Media Model

目的应用计算流体力学(computational fluid dynamics,CFD)技术模拟不同血流导向装置(flow diverter,FD)参数对血流动力学的影响,为术前制定合理治疗策略提供可行方法。方法运用多孔介质模型模拟FD置入动脉瘤的过程,针对特定FD(Tubridge)计算其自身特有的多孔介质动量源参数(渗透率、惯性阻力)初始值。比较不同动量源参数值(初始值80%、90%、100%、110%、120%)情况下血流速度、壁面剪切应力(wall shear stress,WSS)、体积流量、瘤顶压力等血流动力学参数的变化,并进行多孔介质模型针对病人特异性颅内动脉瘤(intracranial aneurysm,IA)血流动力学参数的敏感性分析。结果IA各血流动力学参数对多孔介质模型渗透率的敏感性为:载瘤动脉WSS>瘤体WSS>瘤顶压力,而各参数均对惯性阻力的敏感性较低。结论应用多孔介质模型能够通过选择不同的渗透率参数模拟不同FD金属覆盖率(metal coverage,MC),对不同MC的FD进行建模需要调整特定的渗透率设置。

Objective To simulate the hemodynamic effects of different flow diverters(FD)parameters by using computational fluid dynamics(CFD)technology,so as to develop a more reasonable FD embolization strategy before operation.Methods The porous media model was used to simulate the process of FD implantation into aneurysms,and the initial values of its own unique porous media momentum source parameters(permeability and inertial resistance)were calculated for a specific FD(Tubridge).The changes of hemodynamic parameters such as blood flow velocity,wall shear stress(WSS),volume flow and pressure of aneurysm-roof were compared under different situations(initial values of 80%,90%,100%,110%and 120%),and the sensitivity analysis on hemodynamic parameters of patient-specific intracranial aneurysms(IA)for the porous media model was further conducted.Results The sensitivity of IA hemodynamic parameters to the permeability of porous media model was as follows:WSS_(parent-artery)>WSS_(aneurysm)>p_(aneurysmal-roof),but the sensitivity to inertia resistance was relatively lower.Conclusions By using the porous media model,different metal coverages(MC)of FD could be simulated by choosing different permeability parameters,so it is necessary to adjust specific permeability settings during modeling of FD with different MC.