初级纤毛在关节软骨中的生物力学效应

Biomechanical Effects of Primary Cilia in Articular Cartilage

生物力学因素对于关节软骨的稳态维持具有至关重要的作用。初级纤毛是一种可同时感受力学信号和化学信号的细胞器,并于软骨细胞膜表面也存在有初级纤毛分布。其与多个信号转导通路相关,共同参与软骨细胞表型维持和物质代谢的过程。同时,初级纤毛的异常也关联到多种人类的骨关节类疾病。主要论述初级纤毛在软骨细胞力学微环境中的作用,以及与其他信号通路的交互作用机制,探讨其与骨关节疾病的联系,以期为骨科临床和基础科研提供一定的科学依据。

Biomechanical factors play a crucial role in the steady-state maintenance of articular cartilage.The primary cilium(PC)is a kind of organelle which can sense mechanical and chemical signals at the same time.It is also distributed on the surface of chondrocyte membrane.It is involved in multiple signal transduction pathways as well as in the process of chondrocyte phenotype maintenance and material metabolism.Abnormalities in PC are also associated with a variety of human bone and joint diseases.This paper mainly discusses the mechanism of PC in mechanical microenvironment of chondrocytes and the interaction with other signaling pathways,and explores its relationship with bone and joint diseases,so as to provide some scientific basis for clinical and basic research in orthopedics.