OSAHS合并高血压病与肠道菌群失调机制

Mechanism of obstructive sleep apnea-hypopnea syndrome complicated with hypertension and intestinal flora imbalance

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)已被证明为心血管疾病的独立危险因素,特别是与高血压病关系密切。随着研究的进展,OSAHS合并高血压病患者的肠道细菌的改变,被认为在OSAHS及高血压病的发病及进展过程中可能起到了重要作用。然而肠道菌群的改变是否介导了OSAHS与高血压病的发生目前仍无定论。本文针对OSAHS合并高血压病与肠道菌群改变的关系作一综述。

Obstructive sleep apnea-hypopnea syndrome(OSAHS)has been proved to be an independent risk factor for cardiovascular disease,especially for hypertension.With the progress of research,the changes of intestinal flora in patients with OSAHS complicated with hypertension may play an important role in the pathogenesis and progression of OSAHS-induced hypertension.However,it is still unclear whether the change of intestinal flora mediates the occurrence of OSAHS and hypertension.This article reviews the relationship between OSAHS complicated with hypertension and intestinal flora changes.