糖类抗原125对心力衰竭患者预后预测价值的Meta分析

The prognostic value of carbohydrate antigen 125 in patients with heart failure:a Meta-analysis

目的:采用Meta分析评价血清糖类抗原125(CA125)对心力衰竭患者全因死亡率的影响。方法:检索PubMed、Embase、Web of Science和The Cochrane Library数据库,搜集血清CA125影响心力衰竭患者全因死亡率的前瞻性研究,检索时限均为建库至2020年6月。由两名研究者独立筛选文献、提取资料并用纽卡斯尔-渥太华量表(NOS)对纳入研究进行质量评价。所有数据采用Stata 16.0软件完成Meta分析。结果:共纳入12个前瞻性队列研究,包括4599例心力衰竭患者。Meta分析结果显示,血清CA125水平升高与心力衰竭患者死亡风险增加相关[HR=1.85;95%CI:(1.49,2.31);P<0.001]。结论:血清CA125水平的升高与心力衰竭患者不良预后有关,预后不良程度与CA125水平呈正相关,可作为心力衰竭患者风险分层及预后的特异性指标。

Objective:To evaluate the effect of serum carbohydrate antigen125(CA125)on all-cause mortality in patients with heart failure by using a Meta-analysis.Method:PubMed,Embase,Web of Science,and the Cochrane Library were searched to collect prospective studies about the effect of serum CA125 on all-cause mortality in patients with heart failure from the establishment of the database to June 2020.Two investigators independently screened the literatures,extracted data,and evaluated the quality of included studies by using The Newcastle-Ottawa Scale(NOS).A Meta-analysis was performed using Stata16.0 software.Result:A total of 12 prospective cohort studies with 4599 patients were included.Meta-analysis showed that the elevated serum CA125 level was associated with increased risk of death in patients with heart failure[HR=1.85:95%CI:(1.49,2.31);P<0.001].Conclusion:The increase of serum CA125 level is related to the poor prognosis in patients with heart failure and is positively correlated with the degree of poor prognosis,indicating that serum CA125 level could be used as a specific indicator of risk stratification and prognosis.