骨膜蛋白与梗死后心肌纤维化的相关性研究进展

Advanced progress of the relationship between periostin and post-infraction myocardial fibrosis

急性心肌梗死的产生可导致炎性细胞的大量聚集,进而引起心肌间质中的转化生长因子增高,导致成纤维细胞活化并生成大量的细胞外基质,而骨膜蛋白作为重要的基质蛋白之一,可以对心肌纤维化产生促进作用。本文对骨膜蛋白所介导的梗死后心肌纤维化的作用机制作一综述。

A large number of inflammatory cells accumulate after acute myocardial infarction,which increases the transforming growth factor in the myocardial interstitium and causes activation of fibroblasts and generation of lots of extracellular matrix.Periostin is one of the important extracellular matrix proteins that can promote myocardial fibrosis.This review is about the mechanism of myocardial fibrosis after myocardial infarction mediated by periostin.