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锌指蛋白638在急性胰腺炎中的表达差异和临床意义

The expression level and clinical significance of zinc finger protein 638 in patients with acute pancreatitis
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摘要 目的:探究锌指蛋白638(ZNF638)在急性胰腺炎(AP)早期严重程度评估的临床价值。方法:收集2018年1月—2018年12月期间在我院急诊科入院治疗113例AP患者血清和相关病历资料,同时招募50名健康志愿者为对照组,分析血清中ZNF638表达的差异,统计分析AP患者临床病理参数,分析ZNF638的表达与临床病理参数之间关系。结果:AP患者血液中ZNF638的表达水平明显高于健康对照组,而且ZNF638在轻型急性胰腺炎(MAP)、中重症急性胰腺炎(MSAP)和重症急性胰腺炎(SAP)患者血清中的表达具有明显差异,ZNF638在AP患者血清中表达水平与AP严重程度分级的评分标准具有一致性。结论:AP患者血清中ZNF638的表达水平与AP严重程度分级的评分标准具有一致性,提示ZNF638可以作为AP早期严重程度分级的分子指标。 Objective: To explore the clinical value of ZNF638 in the assessment of severity of acute pancreatitis(Acute pancreatitis, AP) in early stage. Methods: the serum and related medical records of 113 patients and 50 healthy volunteers were collected, and the differences in serum ZNF638 expression, clinical pathological parameters of patients were analyzed. Results: The expression level of ZNF638 in the blood of AP patients was significantly higher than that in the healthy control group, and ZNF638 was effective in mild acute pancreatitis(Mild acute pancreatitis, MAP), moderate severe acute pancreatitis(MSAP) and severe acute pancreatitis.(Severe acute pancreatitis, SAP) The expression in the serum of patients is significantly different, and the expression level of ZNF638 in the serum of AP patients is consistent with the scoring standard of AP severity. Conclusion: The expression level of ZNF638 in the serum of AP patients is consistent with the scoring standard of AP severity, which suggests that ZNF638 can be used as a molecular index for early grading of acute pancreatitis.
作者 潘慧 聂时南 PAN Hui;NIE Shinan(Department of Emergency Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing,210002,China)
出处 《临床急诊杂志》 CAS 2020年第12期974-977,共4页 Journal of Clinical Emergency
关键词 急性胰腺炎 ZNF638 早期严重程度分级 acute pancreatitis ZNF638 early severity grade
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