非编码RNA调控抗甲型流感病毒天然免疫应答的研究进展

Research progress in noncoding RNA involved in regulating innate antiviral immunity against influenza A virus

非编码RNA(noncoding RNA, ncRNA)拥有强大的调控功能,在各种细胞过程(包括细胞生长、分化、存活和凋亡)中发挥着重要作用。甲型流感病毒(influenza A virus, FluA)是一种严重威胁人类健康和畜牧业的重要病原,其与宿主互作机制及过程非常复杂。FluA感染可导致数百个不同宿主ncRNA差异表达,近年来已成为生命科学的研究热点。本文综述了宿主编码ncRNA参与调控FluA感染的研究进展,有助于研究病毒与宿主间的相互作用及发现新的抗病毒策略。

Non-coding RNA(ncRNA)have enormous regulatory functions and play important roles in a variety of cellular processes including cell growth,differentiation,survival and apoptosis.Influenza A virus(FluA)is an important pathogen of serious threats to human health and livestock industry.The interaction mechanism between FluA and the host is very complicated.FluA infection can lead to differential expression of hundreds of host ncRNA,which has become a research hotspot in life sciences in recent years.This review summarizes the progress in different host-encoded ncRNA involved in regulating FluA infection,not only to study the interaction between viruses and hosts,but also to discover new antiviral strategies.