Novel mitochondrial tRNAArg 10461A>G mutation in a pedigree with obesity

Obesity is one of the most prominent public health chailenges globally,with an over tenfold increase in the number of obese children over the last 40 years[1,2].The etiology of obesity,however,is incompletely understood owing to its complex and multifactorial nature[3].Most efforts to identify genetic determinants of childhood obesity have focused on nuclear genes.