摘要
患者男,79岁,慢性荨麻疹样发疹5年,皮损无痛痒感。皮肤科检查示躯干、四肢多发隆起的水肿性红斑,直径1~3 cm不等。实验室检查示血中白细胞及中性粒细胞持续升高,有明显贫血,M蛋白比例升高,IgM轻链κ型免疫电泳单克隆区带,超声提示双腋窝、腹股沟淋巴结肿大,骨显像示腰椎中下段异常放射性浓聚灶,皮损组织病理显示真皮浅中层小血管周围中性粒细胞浸润。诊断为Schnitzler综合征(SS),经小剂量糖皮质激素治疗后,病情缓解。
A 79-year-old male patient presented with history of chronic urticarial exanthema without itching or pain for five years.Skin examination showed widespread elevated edematous erythema,1 cm to 3 cm in diameter.Laboratory examination revealed persistent neutrophilic leukocytosis,anemia and IgMκlight-chain gammopathy.Ultrasonic examination exhibited lymphadenopathy in both axillary and inguinal regions.Positron emission tomography computed tomography showed strong up-take in mid-lower lumbar.Histopathologically,perivascular neutrophil infiltration in mid-upper corium.A diagnosis of Schnitzler syndrome(SS)was defined.The patient received low dose glucocorticoids and conditions was greatly improved.
作者
兰宇贞
张公杰
郭独一
鞠延娇
周芳
李薇薇
张春雷
谢志强
Lan Yuzhen;Zhang Gongjie;Guo Duyi;Ju Yanjiao;Zhou Fang;Li Weiwei;Zhang Chunlei;Xie Zhiqiang(Peking University Third Hospital,Beijing 100191,China)
出处
《中国中西医结合皮肤性病学杂志》
CAS
2021年第1期8-11,共4页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
基金
北京市自然科学基金(7202227)。
