胎儿脐带缠绕与环境暴露因素的关联

The relationship between fetal umbilical cord entanglement and environmental exposure factors

目的了解中国胎儿脐带缠绕现状及其与环境暴露因素的相关性,为预防和干预脐带缠绕提供科学的指导。方法以中国孕产妇队列研究·协和项目的孕妇为研究对象,在孕早期收集孕妇的一般人口学信息和环境暴露信息,随访获取脐带缠绕相关结局,应用多因素非条件Logistic回归分析模型分析胎儿脐带缠绕的影响因素。结果胎儿脐带缠绕的发生率为9.00%。Logistic回归分析模型分析结果显示:调整混杂因素后,与孕期没有暴露于被动吸烟或噪声的孕妇相比,暴露于被动吸烟(OR=1.199, 95%CI:1.010~1.423,P=0.038)或噪声(OR=1.242, 95%CI:1.002~1.541,P=0.048)的孕妇发生脐带缠绕的风险较高。结论孕妇孕期被动吸烟和接触噪声对胎儿脐带缠绕有影响,应加强孕期教育,减少孕妇孕期被动吸烟和噪声环境暴露。

Objective To understand the incidence of fetal umbilical cord entanglement in China and its correlation with environmental exposure factors, so as to provide scientific guidance for prevention and intervention of umbilical cord entanglement. Methods The pregnant women of the Chinese Pregnant Women Cohort Study were selected as the research subjects. The general demographic information and environmental exposure information of pregnant women were collected in the early pregnancy, and the related outcomes of umbilical cord entanglement were obtained by follow-up. Multivariate unconditional Logistic regression analysis model was used to analyze the influencing factors of fetal umbilical cord entanglement. Results The incidence of fetal umbilical cord entanglement was 9.00%. The results of Logistic regression analysis showed that after adjusting for confounding factors, pregnant women exposed to passive smoking(OR=1.199, 95% CI: 1.010-1.423, P=0.038) or noise(OR=1.242, 95% CI: 1.002-1.541, P=0.048) had a higher risk of umbilical cord entanglement than those who were not exposed to passive smoking or noise during pregnancy. Conclusions Passive smoking and exposure to noise during pregnancy can affect fetal umbilical cord entanglement. Education during pregnancy should be strengthened to reduce passive smoking and noise exposure during pregnancy.