中西医结合治疗晚期肺癌临床疗效观察

Clinical Observation on Integrated Chinese-western Therapy on Advanced Lung Cancer

目的观察中西医结合治疗晚期肺癌临床疗效。方法选取我院就诊的92例晚期肺癌患者作为研究对象,采用1∶1完全随机对照试验方法将患者分为对照组与观察组各46例。对照组采用顺铂^(+)吉西他滨进行化疗,观察组在对照组治疗基础上联合采用参芪扶正注射液治疗。比较两组治疗后临床疗效,两组治疗前后肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、S100A8、S100A9水平,T细胞亚群CD3^(+)、CD4^(+)、自然杀伤细胞(NK)细胞占比和CD4^(+)/CD8^(+),中国癌症化疗患者生活质量量表(QLQ-CCC)评分以及两组治疗期间的不良反应发生率。结果治疗后,观察组治疗总有效率与对照组比较差异无统计学意义(P>0.05);且观察组炎性因子TNF-α、IL-6、S100A8和S100A9水平均低于对照组(P<0.05);观察组CD3^(+)、CD4^(+)、NK细胞占比和CD4^(+)/CD8^(+)均比对照组高(P<0.05);观察组躯体、心理、社会功能以及QLQ-CCC总分均高于对照组(P<0.05);观察组恶心呕吐、血小板减少等不良反应发生率明显低于对照组(P<0.05)。结论中西医结合治疗晚期肺癌患者,可以明显改善机体炎性反应状态,提升患者免疫功能和生活质量,减少不良反应的发生,临床疗效较好。

Objective To observe the clinical curative effect of integrated Chinese-western therapy on patients with advanced lung cancer and its influences on inflammatory factors and immune function. Methods A total of 92 patients with advanced lung cancer who were diagnosed in the hospital were enrolled as the research objects. According to completely randomized controlled trial method,they were divided into control group and observation group,46 cases in each. Control group was given cisplatin and gemcitabine for chemotherapy,while observation group was treated with Shenqi Fuzheng Injection on basis of control group. The total response rates of treatment in both after treatment were statistically analyzed. The levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),S100 A8 and S100 A9,proportions of T cell subsets(CD3^(+),CD4^(+))and NK cells, CD4^(+)/CD8^(+),scores of Quality of Life Questionnaire for Chinese Cancer Patients(QLQ-CCC) receiving chemotherapy before and after treatment,and the incidence of adverse reactions during treatment were compared between the two groups. Results After treatment,there was no significant difference in total response rate of treatment between observation group and control group(P>0.05);the levels of inflammatory factors(TNF-α,IL-6,S100 A8,S100 A9)in observation group were lower than those in control group(P<0.05);the proportions of CD3^(+),CD4^(+)and NK cells,and CD4^(+)/CD8^(+)in observation group were higher than those in control group(P<0.05);the physical,psychological and social function scores,and total score of QLQ-CCC in observation group were higher than those in control group(P<0.05);the incidence of adverse reactions(nausea and vomiting,thrombocytopenia)in observation group was significantly lower than that in control group(P<0.05). Conclusion Integrated Chinese-western therapy can significantly improve inflammatory response status,immune function and quality of life,reduce occurrence of adverse reactions in treatment of advanced lung cancer,with good clinical curative effect.