乌拉尔甘草根异戊烯基黄酮类成分的研究

Prenylated flavonoids from Glycyrrhiza uralensis

目的研究乌拉尔甘草Glycyrrhiza uralensis Fisch.根中异戊烯基黄酮类成分。方法乌拉尔甘草95%乙醇提取物乙酸乙酯部位采用硅胶、聚酰胺、Sephadex LH⁃20、半制备HPLC等进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到15个异戊烯基黄酮类化合物,分别鉴定为甘草西定(1)、ulexone A(2)、sophoronol A(3)、lupalbigenin(4)、8⁃prenylluteone(5)、isoderrone(6)、1⁃methoxy⁃phaseollin(7)、甘草利酮(8)、glyurallin A(9)、甘草酚(10)、光甘草素(11)、gancaonin F(12)、1⁃phaseollinisoflavan(13)、gancaonin G(14)、licoisoflavanone C(15)。结论化合物2~5为首次从甘草属植物中分离得到,化合物11~13、15为首次从该植物中分离得到。

AIM To study the prenylated flavonoids from the roots of Glycyrrhiza uralensis Fisch..METHODS The ethyl acetate fraction of 95%ethanol extract from G.uralensis was isolated and purified by silica,polyamide,Sephadex LH⁃20 and semi⁃preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Fifteen prenylated flavonoids were isolated and identified as licoricidin(1),ulexone A(2),sophoronol A(3),lupalbigenin(4),8⁃prenylluteone(5),isoderrone(6),1⁃methoxy⁃phaseollin(7),licoricone(8),glyurallin A(9),glycyrol(10),glabrene(11),gancaonin F(12),1⁃phaseollinisoflavan(13),gancaonin G(14)and licoisoflavanone C(15).CONCLUSION Compounds 2-5 are isolated from the genus Glycyrrhiza for the first time,and compounds 11-13,15 are first isolated from this plant.