武汉市方舱医院117例新型冠状病毒肺炎患者出院后随访结果

Follow-up results of 117 discharged patients with coronavirus disease 2019 in Wuhan Mobile Cabin Hospital

目的对武汉市洪山方舱医院治愈出院的新型冠状病毒肺炎(新冠肺炎)患者进行随访,分析出院患者的流行病学和临床特点以及新型冠状病毒(2019-nCoV)核酸检测结果,为疫情的防控提供依据。方法以电话随访的方式收集2020年2月6日至3月10日武汉市洪山方舱医院收治的117例确诊为新冠肺炎并治愈出院患者的临床资料,并分析其流行病学特点、临床症状、实验室及其影像学检查资料,以期为新冠肺炎的防治提供依据。结果117例达到出院标准的新冠肺炎患者中,男性49例,女性68例;年龄(49.00±11.88)岁,住院时间为(17±6)d,其中91例患者出院后无明显症状(占77.78%),少部分患者出院后有胸闷、心悸、气喘等临床症状,7例患者出院后有胸闷表现,有咽痛和心悸的患者各为5例,4例患者出院后仍有咳嗽表现,有气喘和胸痛的患者均为3例,有头痛、腹泻、呼吸困难的患者各为1例。7例出院患者的2019-nCoV核酸检测呈阳性,复阳率约5.98%,均在达到出院标准后10~19 d出现核酸复阳情况;大部分患者出院后未再行胸部CT检查,但随访时行胸部CT检查的30例患者中有24例表现正常,6例患者CT结果均较出院时吸收或正常。结论武汉市方舱医院新冠肺炎患者出院后存在2019-nCoV核酸复阳现象,未造成续发传播,且这些核酸结果复阳的患者与其住院时间及出院后临床症状存在与否和CT表现无明显相关性。建议对于治愈出院的患者增加粪便或其他标本的检测,同时对出院患者加强定期监测和随访。

Objective To follow up the cured and discharged patients with coronavirus disease 2019(COVID-19)from Wuhan Mobile Cabin Hospital and investigate their epidemiological and clinical characteristics as well as 2019 novel coronavirus(2019-nCoV)nucleic acid test results,so as to provide evidence for epidemic prevention and control.Methods The clinical data including epidemiology,clinical symptoms,laboratory and imaging data of 117 patients diagnosed with COVID-19 who were admitted to Wuhan Hongshan Mobile Cabin Hospital from February 6 to March 10,2020 were collected by telephone follow-up and analyzed,so as to provide evidence for the prevention and treatment of COVID-19.Results Among the 117 COVID-19 patients who met the discharge criteria,there were 49 males and 68 females with an average age of(49.00±11.88)years old,and the average length of hospital stay was(17±6)days.Among them,91 patients had no obvious symptoms after discharge,and the proportion of asymptomatic patients was 77.78%.A small number of patients had clinical symptoms such as chest distress,palpation and asthma,etc.after discharge.After discharge,7 patients had chest distress symptom,5 cases had sore throat and palpitate symptom,4 patients still had cough,asthma and chest pain existed in 3 cases for each,and headache,diarrhea,difficulty in breathing existed in 1 case for each.The 2019-nCoV nucleic acid results of 7 discharged patients were positive,with a re-positive rate of about 5.98%.The nucleic acid positive result occurred after 10-19 days in meeting the discharge standard.Most of the patients did not receive chest CT scan after discharge,but 24 cases of the patients received chest CT scan during follow-up showed normal manifestations,and the lesions of 6 patients were all almost absorbed or normal.Conclusions Some patients with COVID-19 in Wuhan Mobile Cabin Hospital who were re-positive with 2019-nCoV nucleic acid after discharge did not cause further transmission.Moreover,the patients with re-positive nucleic acid results were not significantly correlated with their length of hospital stay and the presence of clinical symptoms after discharge as well as CT findings.It is recommended to detect feces or other specimens in discharged patients,and to strengthen the regular monitoring and follow-up of discharged patients.