预测前列腺癌根治术后生化复发的研究

Study on the Prediction of Biochemical Recurrence After Radical Prostatectomy

前列腺癌患者在行根治性治疗后复发率较高,多数患者会出现生化复发(BCR)。生化复发是提示前列腺癌根治术后复发的重要指标之一,前列腺癌患者根治术后生化复发的预测是目前研究热点。本文就BCR的定义及术前血清前列腺特异抗原水平(PSA)、肿瘤体积、Gleason评分、手术切缘、精囊侵犯、淋巴血管侵犯及手术方式等危险因素在预测前列腺癌患者根治术后生化复发方面的研究作一综述,以期为临床防治BCR提供参考。

Prostate cancer patients have a higher recurrence rate after radical treatment,and most patients will have biochemical recurrence(BCR).Biochemical recurrence is one of the important indicators for the recurrence of prostate cancer after radical resection.The prediction of biochemical recurrence after radical resection of prostate cancer is the current research hotspot.This article focuses on the definition of BCR and preoperative serum prostate-specific antigen levels(PSA),tumor volume,Gleason score,surgical margin,seminal vesicle invasion,lymphatic vessel invasion,and surgical methods in predicting biochemical recurrence in patients with prostate cancer to make a review of the research,it is expected to provide reference for clinical prevention and treatment of BCR.