Ca^(2+)拮抗剂联合利多卡因麻醉在颅脑手术中的应用效果

Application Effect of Ca2+Antagonist Combined with Lidocaine Anesthesia in Craniocerebral Surgery

目的探讨Ca^(2+)拮抗剂联合利多卡因麻醉在颅脑手术治疗中对脑神经功能的作用。方法收集我院2019年1月~2020年1月收治的颅脑手术患者40例,根据麻醉方式不同分为研究组和对照组,每组20例,对照组给予利多卡因麻醉,研究组给予Ca^(2+)拮抗剂联合利多卡因麻醉,比较两组麻醉效果TNF-α、IL-1、NSE与SOD水平以及简化FMA、Barthel指数以及NFA评分。结果研究组定向力恢复时间、言语应答时间、拔管时间、苏醒时间以及自主呼吸恢复时间低于对照组,差异无统计学意义(P>0.05);两组手术前TNF-α、IL-1、NSE、SOD水平比较,差异无统计学意义(P>0.05);手术后观察组TNF-α、IL-1、NSE、SOD指标低于对照组,差异有统计学意义(P<0.05);两组手术前FMA、Barthel指数以及NFA评分比较,差异无统计学意义(P>0.05),手术后观察组NFA低于对照组,简化FMA和Barthel指数高于对照组,差异有统计学意义(P<0.05)。结论Ca^(2+)拮抗剂联合利多卡因麻醉可减少手术对患者颅脑神经功能的损伤,保护患者脑神经,麻醉效果较好。

Objective To explore the effect of Ca^(2+)antagonist combined with lidocaine anesthesia on cranial nerve function during craniocerebral surgery.Methods A collection of 40 patients undergoing craniocerebral surgery in our hospital from January 2019 to January 2020 were divided into study group and control group according to different anesthesia methods,with 20 cases in each group.The control group was given lidocaine anesthesia,and the study group was given Ca^(2+)antagonist combined with lidocaine anesthesia.The anesthesia effects of the two groups were compared with TNF-α,IL-1,NSE and SOD levels,as well as simplified FMA,Barthel index and NFA scores.Results The study group's orientation recovery time,speech response time,extubation time,awakening time and spontaneous breathing recovery time were lower than those of the control group,the difference was not statistically significant(P>0.05);There was no significant difference in the levels of TNF-α,IL-1,NSE,and SOD between the two groups before surgery(P>0.05);After the operation,the TNF-α,IL-1,NSE and SOD indexes of the observation group were lower than those of the control group,the difference was statistically significant(P<0.05);There was no significant difference in FMA,Barthel index and NFA scores between the two groups before surgery(P>0.05).After the operation,the NFA of the observation group was lower than that of the control group,and the simplified FMA and Barthel index were higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Ca^(2+)antagonist combined with lidocaine anesthesia can reduce the damage of craniocerebral nerve function caused by surgery and protect the brain nerve of the patient.The anesthesia effect is better.