粪乳铁蛋白、维生素D水平与克罗恩病患者骨质疏松的相关性

Correlation Between Fecal Lactoferrin,Vitamin D Levels and Osteoporosis in Crohn's Disease

目的评估肠道炎症的严重程度与克罗恩病(CD)患者骨密度(BMD)之间的关系以及维生素D对克罗恩病患者骨密度的影响。方法选取2020年1月~10月在我院就诊的46例克罗恩病患者作为病例组,另外选取同期20例健康体检者作为健康对照组,利用经典CDAI评分标准评估克罗恩病患者的病情严重程度,Lunar Prodigy双能X射线骨密度仪及酶联免疫法评估并比较两组的骨密度、粪乳铁蛋白及维生素D水平,分析克罗恩病患者粪乳铁蛋白水平与CDAI指数,骨密度与粪乳铁蛋白、维生素D水平的相关性。结果病例组乳铁蛋白水平高于健康对照组,差异有统计学意义(P<0.05);病例组骨密度、维生素D水平低于健康对照组,差异有统计学意义(P<0.05);克罗恩病患者骨密度与粪乳铁蛋白、维生素D水平无相关性。结论粪乳铁蛋白含量可以作为反映肠道炎症严重程度,克罗恩病患者易出现骨密度下降,其机制可能与维生素D吸收不良有关。

Objective To evaluate the relationship between the severity of intestinal inflammation and the patient's bone density(BMD)and the effect of vitamin D on the bone density of patients with Crohn's disease(CD).Methods A total of 46 patients with Crohn's disease who were treated in our hospital from January to October 2020 were selected as the case group,and 20 healthy subjects were selected as the healthy control group during the same period.The classic CDAI scoring standard was used to assess the severity of Crohn's disease.The Lunar Prodigy dual-energy X-ray bone densitometer and enzyme-linked immunoassay were used to assess and compare the bone density,fecal lactoferrin and vitamin D levels of the two groups.Analyze the correlation between fecal lactoferrin level and CDAI index,bone density and fecal lactoferrin and vitamin D levels in patients with Crohn's disease.Results The lactoferrin level in the case group was higher than that in the healthy control group,the difference was statistically significant(P<0.05);The bone density and vitamin D levels of the case group were lower than those of the healthy control group,the difference was statistically significant(P<0.05);Tthere was no correlation between bone density and the level of fecal lactoferrin and vitamin D.Conclusion The content of fecal lactoferrin can be used as a reflection of the severity of intestinal inflammation.Patients with Crohn's disease are prone to decrease in bone density,and the mechanism may be related to malabsorption of vitamin D.