氟哌噻吨美利曲辛片联合舒肝解郁胶囊治疗难治性胃食管反流病的疗效

Efficacy of Flupentixol and Melitroxin Tablets Combined with Shugan Jieyu Capsule in the Treatment of Refractory Gastroesophageal Reflux Disease

目的观察氟哌噻吨美利曲辛片联合舒肝解郁胶囊治疗难治性胃食管反流病(GERD)的临床疗效。方法将我院2019年5月~2020年5月收治的82例难治性GERD患者随机分为对照组(n=41)与观察组(n=41),均给予氟哌噻吨美利曲辛片治疗,观察组在此基础上给予舒肝解郁胶囊治疗。比较两组治疗疗效,治疗前后的抑郁症状、临床症状、焦虑症状和生活质量分别采汉密尔顿抑郁量表(HAMD)评分、反流性疾病问卷(RDQ)评分、汉密尔顿焦虑量表(HAMA)和健康调查简易量表(SF-36)评分及不良反应发生情况。结果观察组治疗总有效率为95.12%,高于对照组的70.73%(P<0.05);两组治后HAMD评分、各项RDQ评分和HAMA评分均低于治疗前,SF-36评分高于治疗前(P<0.05),且观察组治疗后HAMD评分、各项RDQ评分和HAMA评分均低于较对照组,SF-36评分较对照组升高(P<0.05)。结论难治性GERD病患者给予氟哌噻吨美利曲辛片用药基础上加以舒肝解郁胶囊治疗,有助于提高临床疗效,改善患者临床症状、焦虑和抑郁状况,提高患者生活质量。

Objective To observe the clinical efficacy of flupentixol and melitroxin tablets combined with Shugan Jieyu capsule in the treatment of refractory gastroesophageal reflux disease(GERD).Methods 82 patients with refractory GERD admitted to our hospital from May 2019 to May 2020 were randomly divided into a control group(n=41)and an observation group(n=41).All patients were treated with flupentixol and melitroxin tablets,and the observation group was treated with Shugan Jieyu capsule on this basis.The therapeutic effects of the two groups were compared.Depressive symptoms,clinical symptoms,anxiety symptoms,and quality of life before and after treatment were assessed using Hamilton Depression Scale(HAMD)score,Reflux Disease Questionnaire(RDQ)score,Hamilton Anxiety Scale(HAMA)and health Investigate the simple scale(SF-36)score and the occurrence of adverse reactions in patients.Results The total effective rate of treatment in the observation group was 95.12%,which was higher than 70.73%in the control group(P<0.05);The HAMD scores,RDQ scores and HAMA scores of the two groups after treatment were lower than those before treatment,and the SF-36 scores were higher than before treatment(P<0.05).After treatment,the HAMD score,RDQ score and HAMA score of the observation group were lower than those of the control group,and the SF-36 score was higher than that of the control group(P<0.05).Conclusion The treatment of patients with refractory GERD disease with Shugan Jieyu Capsule on the basis of flupentixol and melitroxin tablets can help improve clinical efficacy,improve clinical symptoms,anxiety and depression,and improve the quality of life of patients.