GnRHa治疗对特发性中枢性性早熟患儿体质指数及IGF-1水平的影响

Effect of GnRHa treatment on body mass index and IGF-1 level of children with idiopathic central precocious puberty

特发性中枢性性早熟在女童性早熟中占比80%-90%以上,近年来随着社会经济水平的发展、人们生活水平的改善、生活环境的改变等多种因素的影响,性早熟发病率呈逐年增长趋势。其主要可导致骨骺提前闭合,损害成年终身高,引起一系列心理问题。目前国内外普遍采用GnRHa治疗CPP,并取得较好临床效果,但目前国内外对GnRHa治疗对中枢性性早熟患儿BMI的影响尚有争议,对GnRHa治疗中枢性性早熟患儿过程中IGF-1水平的变化的研究相对较少。

Idiopathic central precocious puberty accounts for more than 80%-90% in girls.In recent years,with the development of social and economic level,improvement of people′s living standard,change of living environment and other factors,the incidence of precocious puberty shows an increasing trend year by year.It can lead to epiphyseal closure in advance,damage adult life high,and cause a series of psychological problems.At present,GnRHa is widely used to treat CPP at home and abroad,and good clinical results have been achieved.However,there is still controversy at home and abroad about the effect of GnRHa treatment on BMI of children with central precocious puberty,and relatively few studies have been conducted on the change of IGF-1 level during GnRHa treatment on children with central precocious puberty.