体检人群脂肪肝患病率及危险因素

Prevalence and risk factors of fatty liver disease in a physical examination population

目的调查分析西安市某体检人群脂肪肝患病率及相关危险因素,为今后采取针对性地预防和治疗提供依据。方法选取2017年6月至2019年6月在西安市第三医院具有完整体检资料的健康体检者9096例,确定脂肪肝患病者,同时收集人体测量学、生化免疫指标、疾病史,通过年龄、性别分层研究其患病情况。资料分析采用卡方检验、t检验和多因素Logistic回归。结果9096例调查对象中,共检出脂肪肝2290例,患病率25.18%。男性患病率显著高于女性(P<0.01);女性60~69岁患病率最高(22.67%),男性30~39岁患病率最高(41.29%)。脂肪肝组体质量指数、总胆固醇、三酰甘油、低密度脂蛋白、空腹血糖、血尿酸、收缩压、舒张压的均值水平显著高于非脂肪肝组,高密度脂蛋白显著低于非脂肪肝组(P<0.01);多元回归分析显示,年龄、体质量指数、舒张压、空腹血糖、三酰甘油、总胆固醇、高密度脂蛋白、血尿酸、胆囊疾病是脂肪肝的危险因素。结论西安市体检人群脂肪肝患病率男性高于女性,超质量及肥胖、血脂异常、高血压、高血糖、高尿酸血症及胆囊疾病是其主要危险因素。

Objective To analyze the prevalence and related risk factors of fatty liver disease in a population undergoing physical examination in Xi'an city and provide basis for targeted prevention and treatment of fatty liver in the future.Methods 9096 healthy adults who had physical examination with complete clinical records in Xi'an No.3 hospital were enrolled,identified with FLD.At the same time,anthropometry,biochemical immune indicators and disease history were collected,and the disease status was studied with age and gender stratification.Data analysis was performed using theχ2 test,t-test,and logistic regression analysis.Results Among the 9096 cases,a total of 2290 cases of FLD were detected with ultrasound examination,with a prevalence rate of 25.18%.The prevalence was significantly higher in males than that in females(P<0.01).The prevalence was highest in females aged 60-69 years(22.67%)and highest in males aged 30-39 years(41.29%).The mean levels of body mass index,total cholesterol,triglyceride,low-density lipoprotein,fasting blood glucose,blood uric acid,systolic blood pressure and diastolic blood pressure in the fatty liver group were significantly higher than those in the non-fatty liver group,while the high-density lipoprotein was significantly lower than those in the non-fatty liver group(P<0.01).Multivariate logistic regression analysis showed that age,body mass index,diastolic blood pressure,fasting blood glucose,triglyceride,total cholesterol,blood uric acid,gallbladder disease were risk factors for fatty liver.Conclusion The prevalence of FLD is higher in males than in females among the physical examination population in xi'an city.Overweight and obesity,dyslipidemia,hypertension,hyperglycemia,hyperuricemia and gallbladder disease were the main risk factors.