以夫妻为中心的心理干预对乳腺癌患者心理健康状况影响的Meta分析

Effects of couple-based psychological interventions on psychological status of patients with breast cancer:a meta-analysis

目的系统评价以夫妻为中心的心理干预对乳腺癌患者心理健康状况的影响。方法在Web of Science、PubMed、Cochrane Library、CNKI、万方数据库收集关于以夫妻为中心的心理干预对乳腺癌患者心理健康状况影响的随机对照实验,检索时限为建库至2020年5月。2名研究者按照纳入和排除标准独立筛选文献、提取资料和评价文献质量后,采用RevMan 5.3软件进行Meta分析。结果纳入7篇文献,共包括1093名患者。描述性结果显示,以夫妻为中心的心理干预可降低乳腺癌患者的癌症复发恐惧;Meta分析结果显示,以夫妻为中心的心理干预对缓解乳腺癌患者的焦虑(SMD=0.04,95%CI=-0.11~0.19,P=0.63)和抑郁(SMD=0.05,95%CI=-0.20~0.10,P=0.54)无明显作用。结论以夫妻为中心的心理干预可降低乳腺癌患者的癌症复发恐惧,对乳腺癌患者焦虑、抑郁症状的改善不明显。由于本研究纳入的文献数量以及样本量相对较少,以上结论尚需进一步验证。

Objective To identify the effects of couple-based psychological interventions on psychological status of patients with breast cancer by using meta-analysis.Methods We performed a systematic search in Web of Science,PubMed,Cochrane Library,CNKI and Wanfang to collect studies about effects of couple-based psychological interventions on psychological status in patients with breast cancer from inception to May 2020.Meta-analysis was performed by using RevMan 5.3 software after two independent reviewers conducted independent literature screening,data extraction,and literature quality evaluation according to inclusion and exclusion criteria.Results Seven studies were recruited,including 1093 patients.Descriptive result displayed that couple-based psychological interventions had a positive effect on fear of cancer recurrence of patients with breast cancer.The results of meta-analysis showed that couple-based psychological interventions had no significant effect on anxiety(SMD=0.04,95%CI=-0.11~0.19,P=0.63)or depress(SMD=0.05,95%CI=-0.20~0.10,P=0.54)of patients with breast cancer.Conclusion Couple-based psychological interventions have a positive effect on fear of cancer recurrence of patients with breast cancer,but have no significant effect on anxiety or depress.Due to limited quality and quantity of the included studies,more high-quality studies are required to verify above conclusion.