丙泊酚对睡眠障碍患者无痛人工流产术后睡眠质量的影响

EFFECT OF PROPOFOL ON SLEEP QUALITY OF PATIENTS WITH SLEEP DISORDERS AFTER PAINLESS INDUCED ABORTION

目的观察丙泊酚对睡眠障碍患者无痛人工流产术后睡眠质量的影响。方法根据术前匹兹堡睡眠质量指数(PSQI)评分,选取行无痛人工流产的患者110例,其中睡眠障碍(PSQI>5分)患者(D组)和无睡眠障碍(PSQI≤5分)患者(S组)各55例,静脉给予丙泊酚2.0 mg/kg进行麻醉,分别在术前(T0)及术后7 d(T1)和30 d(T2)进行PSQI及其各指标评分。结果去除失访人数后,D组纳入48例,S组纳入50例。与S组相比,T0时D组的PSQI、主观睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠紊乱和日间功能障碍得分较高(F=7.545~149.335,P<0.05),T1时PSQI、主观睡眠质量、睡眠时间和日间功能障碍得分较高(F=5.729~17.462,P<0.05),T2时的PSQI、主观睡眠质量和入睡时间得分较高(F=9.878~16.462,P<0.05)。与T0时比较,D组患者T1时的PSQI、入睡时间和睡眠效率得分明显降低(F=5.807~8.088,P<0.05),T2时的PSQI、入睡时间和睡眠时间得分明显降低(F=4.640~19.538,P<0.05);S组T1时睡眠效率得分明显升高(F=10.272,P<0.05)。结论丙泊酚对接受无痛人工流产的睡眠障碍患者术后7 d和30 d的睡眠质量可能有改善作用,而对无睡眠障碍患者的睡眠质量可能无明显影响。

Objective To investigate the effect of propofol on sleep quality of patients with sleep disorders after painless induced abortion.Methods A total of 110 patients who underwent painless induced abortion were enrolled,and according to preoperative Pittsburgh Sleep Quality Index(PSQI)score,55 patients with sleep disorders(PSQI>5)were enrolled as group D,and 55 patients without sleep disorders(PSQI≤5)were enrolled as group S.The patients were given anesthesia with propofol 2.0 mg/kg,and the scores of PSQI and its indices were evaluated before surgery(T0)and at 7 days(T1)and 30 days(T2)after surgery.Results After the patients lost to follow-up were removed,48 patients were enrolled in group D and 50 were enrolled in group S.Compared with group S,group D had significantly higher scores of PSQI,subjective sleep quality,sleep latency,sleep duration,sleep efficiency,sleep disturbance,and daytime dysfunction at T0(F=7.545-149.335,P<0.05),significantly higher scores of PSQI,subjective sleep quality,sleep duration,and daytime dysfunction at T1(F=5.729-17.462,P<0.05),and significantly higher scores of PSQI,subjective sleep quality,and sleep latency at T2(F=9.878-16.462,P<0.05).Group D had significant reductions in the scores of PSQI,sleep latency,and sleep efficiency from T0 to T1(F=5.807-8.088,P<0.05)and significant reductions in the scores of PSQI,sleep latency,and sleep duration from T0 to T2(F=4.640-19.538,P<0.05),while group S had a significant increase in the score of sleep efficiency from T0 to T1(F=10.272,P<0.05).Conclusion Propofol may improve the sleep quality of patients with sleep disorders who undergo painless induced abortion at 7 and 30 days after surgery,but it may not have a significant effect on the sleep quality of patients without sleep disorders.