高尿酸血症与房颤相关性及机制研究进展

Research progress on the relationship and mechanism between hyperuricemia and atrial fibrillation

心房颤动(atrial fibrillation)是临床上最常见的心律失常,显著增加了脑卒中、心衰和心源性死亡的风险。近年来,高尿酸血症与心血管疾病的相关性备受关注。高尿酸血症可通过炎症、氧化应激等途径促进高血压、冠心病等心血管疾病的发生。炎症和氧化应激是导致心脏电生理和结构重构的重要机制。流行病学研究表明高尿酸血症与房颤发生显著相关。然而,高尿酸是否通过炎症、氧化应激等途径导致房颤尚不清楚。本文结合国内外研究,对高尿酸血症与房颤的相关性以及高尿酸血症导致房颤的可能机制进行综述。

Atrial fibrillation is the most common arrhythmia in clinical settings,which significantly increases the risk of stroke,heart failure and cardiac death.In recent years,much attention has been paid to the relationship between hyperuricemia and cardiovascular disease.Hyperuricemia can promote the occurrence of cardiovascular diseases such as hypertension and coronary heart disease through inflammation and oxidative stress.Inflammation and oxidative stress are important mechanisms leading to cardiac electrophysiological and structural remodeling.Epidemiological studies have shown that there is a significant correlation between hyperuricemia and atrial fibrillation.However,it is not clear whether high uric acid leads to atrial fibrillation through inflammation and oxidative stress.In this article,the correlation between hyperuricemia and atrial fibrillation and the possible mechanism of hyperuricemia leading to atrial fibrillation are reviewed.