糖皮质激素炎症通路研究现状

Research status of glucocorticoid inflammatory pathways

糖皮质激素(glucocorticoid,GC)由于其强大的抗炎和免疫抑制等作用被广泛应用于临床。但是,随着对GC认识的深入,研究者们发现GC还能发挥促炎作用,这种效应甚至是机体活动所必须的。机体对GC的反应取决于GC的浓度、机体免疫系统的生理状态、刺激持续时间(急性或慢性)以及疾病的类型等。此外,越来越多的患者出现了对GC反应性差甚至是无反应的状况,临床上常称之为糖皮质激素抵抗(glucocorticoid resistance,GCR)。GC炎症通路上的糖皮质激素受体(glucocorticoid receptor,GR)和下游炎症因子都可能导致GCR的发生。因此,本文就GC炎症通路研究现状等方面进行相关综述。

Glucocorticoid(GC)is widely used clinically due to its powerful anti-inflammatory and immunosuppressive effects.However,with its deeper understanding,researchers have found that GC can also play pro-inflammatory effects,which is even necessary for body activity.The body's response to GC depends on the concentration of GC,the physiological state of the body's immune system,the duration of stimulation(acute or chronic),and the type of disease.In addition,more and more patients have poor or even no response to GC,which is often clinically referred as glucocorticoid resistance(GCR).Both glucocorticoid receptor(GR)and downstream inflammatory factors in the GC inflammation pathway may cause GCR.This article reviews the current research status of GC inflammatory pathways.