银杏二萜内酯葡胺注射液对老年缺血性脑卒中患者神经、血管保护作用及安全性分析

Analysis of neuroprotection,vascular protection and safety of ginkgo diterpene lactone meglumine injection in elderly patients with cerebral ischemic stroke

目的探讨银杏二萜内酯葡胺注射液在老年缺血性脑卒中(CIS)患者神经、血管保护及安全性作用。方法112例老年CIS患者,依据随机数字表法分为观察组和对照组,每组56例。对照组采取常规治疗,研究组于对照组基础上加用银杏二萜内酯葡胺注射液治疗。比较两组患者临床疗效、不良反应发生情况以及治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)评分、脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)、一氧化氮(NO)、抵抗素(resistin)、内皮素-1(ET-1)、降钙素基因相关肽(CGRP)水平。结果治疗后,两组患者NIHSS评分均低于治疗前、BI评分均高于治疗前,且研究组患者NIHSS评分低于对照组、BI评分高于对照组,差异均具有统计学意义(P<0.05)。研究组治疗总有效率91.07%高于对照组的76.79%,差异具有统计学意义(P<0.05)。治疗后,两组BDNF高于治疗前、NSE低于治疗前,且研究组BDNF高于对照组、NSE低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组NO及CGRP水平均高于治疗前、resistin及ET-1水平均低于治疗前,且研究组NO及CGRP水平均高于对照组、resistin及ET-1水平均低于对照组,差异具有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论采取银杏二萜内酯葡胺注射液治疗老年CIS患者,利于神经功能及日常生活能力改善,可对神经及血管产生良好保护作用,提高疾病整体治疗效果,且不会增加不良反应,具有安全性。

Objective To discuss the effect of ginkgo diterpene lactone meglumine injection protects nerve and blood vessels in elderly patients with cerebral ischemic stroke(CIS).Methods A total of 112 elderly CIS patients were divided into observation group and control group according to random numerical table,with 56 cases in each group.The control group was treated with conventional therapy,and the research group was treated with ginkgo diterpene lactone meglumine injection based on the control group.The clinical efficacy,occurrence of adverse reactions,and National Institutes of Health stroke scale(NIHSS)score,Barthel index(BI)score,brain-derived neurotrophic factor(BDNF),neuron-specific enolase(NSE),nitric oxide(NO),resistin,endothelin(ET-1),calcitonin gene-related peptide(CGRP)levels before and after treatment were compared between the two groups.Results After treatment,the NIHSS score of the two groups were lower than that before treatment,and BI score was higher than that before treatment.The NIHSS score of the research group was lower than that of the control group,and BI score was higher than that of the control group.All the difference was statistically significant(P<0.05).The total effective rate of treatment 91.07%of the research group was higher than 76.79%of the control group,and the difference was statistically significant(P<0.05).After treatment,the BDNF of the two groups was higher than that before treatment,and NSE was lower than that before treatment.The BDNF of the research group was higher than that of the control group,and NSE was lower than of the control group.All the difference was statistically significant(P<0.05).After treatment,the NO and CGRP of the two groups were higher than those before treatment,and resistin and ET-1 were lower than those before treatment.The NO and CGRP of the research group were higher than those of the control group,and the resistin and ET-1 were lower than the control group.All the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Ginkgo diterpenoid lactone meglumine injection in the treatment of elderly patients with CIS is conducive to the improvement of neurological function and activities of daily living.It has a good protective effect on nerves and blood vessels,and can improve the overall treatment effect of the disease without increase of adverse reactions,so it is safe.