不同钙离子拮抗剂治疗血管痉挛性心绞痛的疗效观察

Observation on the therapeutic effect of different calcium antagonists on vasospastic angina

目的分析不同钙离子拮抗剂治疗血管痉挛性心绞痛(VSA)的临床疗效。方法120例VSA患者,按照入院先后顺序分为观察1组及观察2组,每组60例。观察1组采用贝尼地平治疗,观察2组采用氨氯地平治疗。比较两组患者的临床疗效、不良事件发生情况、心电图缺血性变化情况以及心功能[左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)]水平。结果两组治疗总有效率及肢端水肿、血管扩张发生率比较,差异无统计学意义(P>0.05)。治疗后,两组患者的ST段下移导联数、T波低平导联数、T波倒置导联数、LVEDD、LVEF均较治疗前改善,且观察1组的ST段下移导联数(1.96±0.50)、T波低平导联数(1.82±0.80)、T波倒置导联数(1.25±0.70)均低于观察2组的(2.65±0.80)、(2.30±0.92)、(2.98±0.80),差异具有统计学意义(P<0.05)。结论氨氯地平、贝尼地平钙离子拮抗剂均可用于防治VSA,其中,贝尼地平预后情况更好。

Objective To analyze the clinical efficacy of different calcium antagonists on vasospastic angina(VSA).Methods A total of 120 VAS patients were divide into observation group 1 and observation group 2 according to admission order,with 60 cases in each group.Observation group 1 was treated with benidipine,and observation group 2 was treated with amlodipine.The clinical efficacy,occurrence of adverse events,electrocardiogram ischemic changes and cardiac function[left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)]level were compared between the two groups.Results There was no statistically significant different in total effective rate of treatment,incidence of acral edema and vasodilation between the two groups(P>0.05).After treatment,the number of ST-segment down leads,the number of T wave low flat leads and the number of T wave inverted leads,LVEDD and LVEF of the two groups were better than those before treatment,and the number of ST-segment down leads(1.96±0.50),the number of T wave low flat leads(1.82±0.80)and the number of T wave inverted leads(1.25±0.70)of observation group 1 were all lower than(2.65±0.80),(2.30±0.92)and(2.98±0.80)of observation group 2.The difference was statistically significant(P<0.05).Conclusion Both amlodipine and benidipine calcium antagonists can be used to prevent and treat VSA,among which benidipine has a better prognosis.