动脉粥样硬化性脑梗死血清LP-PLA2、MMP-13与动脉狭窄程度的关系

The relationship between serum LP⁃PLA2,MMP⁃13 and the degree of arterial stenosis in patients with atherosclerotic cerebral infarction

目的探讨动脉粥样硬化性脑梗死患者血清脂蛋白相关磷脂酶A2(Lp-PLA2)、基质金属蛋白酶13(MMP-13)表达及与动脉狭窄程度的相关性。方法选取2016年12月至2019年12月本院收治的92例动脉粥样硬化性急性脑梗死患者作为观察组,选取同期在本院进行体检的86例健康人群设为对照组。对比两组血清Lp-PLA2、MMP-13水平,并采用Logistic回归模型分析影响动脉粥样硬化性脑梗死患者颈动脉狭窄程度的危险因素,通过ROC曲线分析Lp-PLA2、MMP-13及二者联合检测对动脉粥样硬化性脑梗死患者动脉狭窄程度的预测价值。结果观察组MMP-13、Lp-PLA2水平显著高于对照组,差异具有统计学意义(P<0.05)。总胆固醇、甘油三酯、低密度脂蛋白、吸烟、NIHSS评分、MMP-13、Lp-PLA2为影响动脉粥样硬化性脑梗死患者动脉狭窄程度的单因素(P<0.05)。总胆固醇、甘油三酯、低密度脂蛋白、吸烟、NIHSS评分、MMP-13、Lp-PLA2为影响动脉粥样硬化性脑梗死患者动脉狭窄程度的独立危险因素(P<0.05)。采用ROC曲线分析MMP-13、Lp-PLA2及二者联合曲线下面积分别为0.794、0.889、0.953,各指标曲线下面积以联合检测最大。结论可通过加强监测MMP-13、Lp-PLA2水平,了解动脉粥样硬化性脑梗死患者病情情况,MMP-13及Lp-PLA2可作为判断动脉粥样硬化性脑梗死患者动脉血管狭窄程度的重要指标。

Objective To investigate the expression of serum lipoprotein⁃associated phospholipase A2(Lp⁃PLA2)and matrix metalloprotein⁃13(MMP⁃13)in patients with atherosclerotic cerebral infarction and their relationship with the degree of arterial stenosis Relevance.Methods 92 patients with atherosclerotic acute cerebral infarction admitted to our hospital from December 2016 to December 2019 were selected as the observation group.86 healthy people who underwent physical examination in our hospital during the same period were selected and set as the control group.The serum levels of Lp⁃PLA2 and MMP⁃13 were compared between the two groups,and the logistic regression model was used to analyze the risk factors affecting the degree of carotid artery stenosis in patients with atherosclerotic cerebral infarction.The ROC curve was used to analyze the predictive value of Lp⁃PLA2,MMP⁃13 and the combination of the two in the degree of arterial stenosis in patients with atherosclerotic cerebral infarction.Results The levels of MMP⁃13 and Lp⁃PLA2 in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Total cholesterol,triglycerides,high⁃density lipoprotein,low Density lipoprotein,smoking,NIHSS score,MMP⁃13,Lp⁃PLA2 are the single factor that affects the degree of arterial stenosis in patients with atherosclerotic cerebral infarction(P<0.05).Total cholesterol,triglycerides,low⁃density lipoprotein,smoking,NIHSS score,MMP⁃13,Lp⁃PLA2 is an independent risk factor affecting the degree of arterial stenosis in patients with atherosclerotic cerebral infarction(P<0.05).The area under the curve of MMP⁃13,Lp⁃PLA2 and the combination of the two were 0.794,0.889,0.953,respectively,and the area under the curve of each indicator was the largest in the combined test.Conclusion MMP⁃13 and Lp⁃PLA2 can be used as important indicators to judge the degree of arterial vascular stenosis in patients with atherosclerotic cerebral infarction.