外周血Ⅱ型干扰素调节因子和T淋巴细胞与脑出血的关系研究

Study on the relationship between typeⅡinterferon regulatory factor and T lymphocytes in peripheral blood and cerebral hemorrhage

目的研究外周血Ⅱ型干扰素调节因子γ-干扰素(IFN-γ)和T淋巴细胞(CD4、CD8)与脑出血的关系。方法选取本院2019年1月至2020年6月收治的100例脑出血患者为观察组,另选取同期70名健康体检者为对照组,对比两组以及观察组内不同分期、不同病情程度患者外周血IFN-γ、CD4、CD8表达水平,利用Spearman相关性分析法检验外周血IFN-γ、CD4、CD8表达水平与脑出血患者分期、病情程度的相关性。结果观察组外周血IFN-γ、CD4、CD8表达水平均低于对照组,差异有统计学意义(P<0.05);观察组内超急性期患者外周血IFN-γ、CD4、CD8表达水平高于急性期患者,差异有统计学意义(P<0.05);观察组内外周血IFN-γ、CD4、CD8表达水平随着病情程度的提升而下降,差异有统计学意义(P<0.05);Spearman相关性分析结果提示,外周血IFN-γ、CD4、CD8表达水平与脑出血患者分期、病情程度均呈负相关性(P<0.05)。结论外周血Ⅱ型干扰素调节因子IFN-γ和T淋巴细胞CD4、CD8参与到了脑出血的发生、发展之中,对今后临床评估脑出血患者分期、病情严重程度具有一定的帮助价值。

Objective To study the relationship betweenγ⁃Interferon(IFN⁃γ)and T lympho⁃cytes(CD4,CD8)and cerebral hemorrhage.Methods A total of 100 patients with cerebral hemorrhage ad⁃mitted to our hospital from January 2019 to June 2020 were selected as the observation group,and another 70 healthy physical examination subjects during the same period were selected as the control group.The expres⁃sion levels of peripheral blood IFN⁃γ,CD4,and CD8 were compared between the two groups and the observa⁃tion group in patients with different stages and different disease levels.Spearman correlation analysis method was used to test the expression levels of peripheral blood IFN⁃γ,CD4,and CD8 with cerebral hemorrhage pa⁃tients.Results The expression levels of peripheral blood IFN⁃γ,CD4,and CD8 in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The ex⁃pression levels of peripheral blood IFN⁃γ,CD4 and CD8 in the hyperacute phase of the observation group were higher than those of the acute phase,and the difference was statistically significant(P<0.05);In the ob⁃servation group,the expression levels of IFN⁃γ,CD4,and CD8 in peripheral blood decreased with the improvement of the disease,and the difference was statistically significant(P<0.05).The results of Spearman correlation analysis showed that the expression levels of peripheral blood IFN⁃γ,CD4,and CD8 were nega⁃tively correlated with the stage and severity of cerebral hemorrhage patients(P<0.05).Conclusion Peripher⁃al blood IFN⁃γand T lymphocytes CD4 and CD8 are involved in the occurrence and development of cerebral hemorrhage,and have certain helpful value for clinical evaluation of the stage and severity of cerebral hemor⁃rhage patients in the future.