颈动脉超声联合CT和血清miR-124、miR-155对颈动脉狭窄患者继发性脑梗的风险预测价值

Value of Carotid Ultrasound Combined with CT and Serum miR-124 and miR-155 in Predicting the Risk of Secondary Cerebral Infarction in Patients with Carotid Stenosis

本文探讨了颈动脉超声检查联合CT和血清微小RNA-124(miR-124)、微小RNA-155(miR-155)对颈动脉狭窄患者继发性脑梗的风险预测价值。以43例颈动脉狭窄患者为颈动脉狭窄组,正常志愿者43例为正常组,用RT-PCR法检测miR-124、miR-155表达,采用颈动脉超声检查颈动脉狭窄,采用CT检查颈部血管。结果显示,与正常组相比,颈动脉狭窄组miR-124、miR-155表达升高(P<0.05)。与超声、CT检查相比,超声检查联合CT检查颈动脉狭窄准确率、诊断价值较高(P<0.05)。本研究认为,颈动脉超声、CT、miR-124、miR-155对颈动脉狭窄的诊断价值较高,且可用于预测继发性脑梗的风险,预测价值较为理想。

This study explored the value of carotid ultrasound combined with CT and serum microRNA-124(miR-124)and microRNA-155(miR-155)in predicting the risk of secondary cerebral infarction in patients with carotid stenosis.Forty-three patients with carotid stenosis were selected as carotid stenosis group,and 43 normal volunteers were selected as normal group.The expression of miR-124 and miR-155 was detected by RT-PCR.Carotid artery stenosis was examined by carotid ultrasound.The blood vessels in the neck were examined by CT.The results showed that compared with the normal group,the expression of miR-124 and miR-155 in carotid stenosis group was increased(P<0.05).Compared with ultrasound and CT,ultrasound combined with CT had higher accuracy and diagnostic value(P<0.05).It is found that carotid ultrasound,CT,miR-124 and miR-155 have high diagnostic value for carotid artery stenosis,and can be used to predict the risk of secondary cerebral infarction.