水通道蛋白在动物疾病发生过程中的作用研究进展

Progress on Effects of Aquaporins in Occurrence of Animal Diseases

水通道蛋白(AQP)是细胞上存在的一种膜孔道蛋白。动物、植物、微生物细胞上均有水通道蛋白的表达,其主要功能是参与机体的水与电解质代谢。近年来,针对水通道蛋白在机体所发挥的功能方面研究较多,发现水通道蛋白不仅参与机体生理方面的调控,而且在一些疾病的发生发展过程中也发挥重要的作用。综述概括了水通道蛋白在脑、肺、肾脏、肠道等组织器官的定位;重点阐述了水通道蛋白在动物脑部疾病、肺部疾病、肾脏疾病、肠道疾病发展过程中所发生的变化。旨在为患病动物出现水与电解质代谢紊乱症状时,对水通道蛋白发生的变化研究提供参考。

Aquaporins are a kind of membrane channel proteins present in cells.Aquaporins are expressed in animal,plant and microbial cells,and the main function of aquaporins is to participate in the metabolism of water and electrolytes in the body.In recent years,there are many studies on the function of aquaporins in the body,and it is found that aquaporins not only participate in the physiological regulation of the body,but also play an important role in the occurrence and development of some diseases.This review presumptively summarized the localization of aquaporins in brain,lung,kidney and intestine,emphatically illuminated the changes of aquaporins in the development of brain disease,lung disease,kidney disease and intestinal disease.The aim is to provide a reference for the study of the changes of aquaporins in diseased animals with symptoms of water and electrolytes metabolism disorder.