阿仑膦酸钠对绝经后骨质疏松症患者骨折的预防效果

Preventive Effect of Alendronate on Fracture in Postmenopausal Patients with Osteoporosis

目的:探究阿仑膦酸钠对绝经后骨质疏松症(PMO)患者骨折的预防效果。方法:将2017年10月至2019年9月鄱阳县人民医院收治80例PMO患者按照硬币投掷的方法分为观察组(n=40)及对照组(n=40)。对照组予以常规基础治疗,观察组予以阿仑膦酸钠治疗,持续治疗6个月。比较两组骨密度(左股骨、L1-4椎体)、骨代谢指标及疼痛情况变化,并记录两组随访1年期间骨折事件发生率。结果:治疗6个月后,两组患者左股骨、L1-4椎体骨密度值均上升(P<0.05),而BGP、TRACP-5b、CTX水平及VAS评分较治疗前均下降(P<0.05),且观察组上述指标变化幅度更大(P<0.05);随访1年期间,观察组骨折率为5%,低于对照组的20%(P<0.05)。结论:阿仑膦酸钠可明显改善PMO症状,提升患者骨密度水平,且能显著改善患者疼痛,预防骨折。

Objective:To explore the preventive effect of alendronate sodium on fracture in postmenopausal osteoporosis(PMO)patients.Methods:80 patients with PMO in Poyang County People's Hospital were randomly divided into observation group(n=40)and control group(n=40).The control group was treated with routine basic treatment,and the observation group was treated with alendronate sodium,The treatment lasted for 6 months.The changes of bone mineral density(left femur,L1-4 vertebral body),bone metabolism index and pain were compared between the two groups,and the incidence of fracture events during 1-year follow-up were recorded.Results:After 6 months of treatment,the bone mineral densities of left femur and L1-4 vertebral body were increased in the two groups(P<0.05)while the levels of BGP,TRACP-5b and CTX and VAS score were decreased compared with those before treatment(P<0.05),and the changes of the above indexes were greater in observation group(P<0.05).During 1 year of follow-up,the fracture rate in observation group was lower than that in control group(5%vs 20%)(P<0.05).Conclusion:Alendronate sodium can significantly improve PMO symptoms,enhance bone mineral density,and significantly improve pain and prevent fractures.