贝那普利与厄贝沙坦对原发性高血压患者血压变异性的影响

The Effect of Benazepril and Irbesartan on Blood Pressure Variability in Patients with Essential Hypertension

目的:探讨贝那普利与厄贝沙坦对原发性高血压患者血压变异性(BPV)的影响。方法:回顾性分析2016年1月至2020年3月龙南县中医院收治的80例原发性高血压患者临床资料。根据治疗方式的不同分为对照组和观察组。对照组采用贝那普利治疗,观察组采用厄贝沙坦治疗。两组均连续观察5周。比较两组动态血压情况及BPV值。结果:两组治疗后收缩压水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组治疗后舒张压较治疗前均降低,但组间比较,差异无统计学意义(P>0.05);两组治疗后BPV值均降低,且观察组降幅大于对照组[夜间DBP变异(nDBPSD)除外],差异有统计学意义(P<0.05)。结论:贝那普利、厄贝沙坦治疗原发性高血压均可改善24h动态血压,降低BPV,且厄贝沙坦效果更佳。

Objective:To investigate the effects of benazepril and irbesartan on blood pressure variability(BPV)in patients with essential hypertension.Methods:The clinical data of 80 patients with essential hypertension who were received by Longnan Chinese Medicine Hospital from January 2016 to March 2020 were retrospectively analyzed.According to different treatment methods,those patients were divided into control group and observation group.The control group was treated with benazepril and the observation group was treated with irbesartan.The ambulatory blood pressure and BPV values of the two groups were compared.Results:The systolic blood pressure of the two groups decreased after treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the diastolic blood pressure of the two groups after treatment was lower than before treatment,but there was no statistically significant difference between the groups(P>0.05).The BPV value of both groups was decreased after treatment,and the decrease of the observation group was more than that of the control group[except for DBP variation at night(nDBPSD)],the difference was statistically significant(P<0.05).Conclusion:Benazepril and irbesartan can improve the 24 h ambulatory blood pressure and reduce BPV in the treatment of essential hypertension,and the effect of irbesartan is better.