卵巢癌组织中SSBP1的表达意义及作用

Expression and Significance of SSBP1 in Ovarian Cancer

目的探讨线粒体DNA单链结合蛋白SSBP1在卵巢癌(Ovarian cancer)组织中的表达水平变化及其意义。方法从The Cancer Genome Atlas(TCGA)数据库中选取经转录组测序分析的正常卵巢组织97例及卵巢癌组织373例,分析癌组织中SSBP1的表达变化,并利用Kaplan-Meier模型分析SSBP1与患者生存情况,Log-rank检验比较生存曲线,最后利用MTS实验研究SSBP1对卵巢癌细胞生长的影响。结果SSBP1在卵巢癌组织中的表达显著低于正常卵巢组织,且肿瘤组织中低表达SSBP1的患者预后显著差于高表达组患者(P<0.01)。过表达SSBP1可显著抑制CRC细胞系的增殖能力。结论SSBP1的表达水平有望成为一种新型标志物用于卵巢癌患者预后评估及药物治疗靶点。

Objective To study the expression and significance of SSBP1 in ovarian cancer.Methods The mRNA expression levels of SSBP1 in 97 normal ovary and 373 ovarian cancer tissues were extracted and calculated from The TCGA database.The Kaplan-Meier method and log-rank test were used to assess the prognostic significance.Moreover,the effects of SSBP1 on the proliferation of ovarian cancer cells were also determined by MTS assay.Results The expression of SSBP1 in ovarian cancer tissues was significantly lower than that in normal ovary tissues,and the prognosis of patients with low expression of SSBP1 in tumor tissues was significantly worse than that of patients with high expression(P<0.01).In addition,we found that forced expression of SSBP1 significantly inhibited the tumor growth of ovarian cancer cells.Conclusion The expression of SSBP1 may be a prognostic factor and potential drug target for ovarian cancer patients.