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DPP-4抑制剂辅助治疗2型糖尿病_(T_(2)DM)_患者的效果及对其氧化应激及炎症反应的影响 被引量:2

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摘要 选取2017年3月至2018年4月T_(2)DM患者128例,随机平分为对照组行常规降血糖治疗,实验组加用DDP-4抑制剂治疗。结果治疗后实验组空腹血糖(FBG)及胰岛素抵抗指数低于对照组,脂质过氧化氢(LHP)和MDA含量均低于对照组,总抗氧化能力(T-AOC)和谷胱甘肽过氧化物酶(GSH-Px)含量均高于对照组,炎症因子C反应蛋白、IL-1及IL-6均低于对照组(P<0.05)。结论 DDP-4抑制剂治疗T_(2)DM患者能有效控制血糖及氧化应激和炎症反应。
出处 《实用糖尿病杂志》 2021年第1期67-67,共1页 Journal of Practical Diabetology
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  • 1周健,喻明,贾伟平,李青,李鸣,马晓静,陆蔚,项坤三.应用动态血糖监测系统评估2型糖尿病患者日内及日间血糖波动幅度[J].中华内分泌代谢杂志,2006,22(3):286-288. 被引量:177
  • 2Morrish NJ,Wang SL,Stevens LK,et al.Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes[J].Diabetologia,2001,44(2):S14-21.
  • 3An Y,Zhang P,Wang J,et al.Cardiovascular and All-Cause Mortality Over a 23-Year Period Among Chinese With Newly Diagnosed Diabetes in the Da Qing IGT and Diabetes Study[J].Diabetes Care,2015,38(7):1365-1371.
  • 4Dicker D.DPP-4 Inhibitors Impact on glycemic control and cardiovascular risk factors[J].Diabetes Care,2011,34(Suppl 2):S276-278.
  • 5Scheen AJ.Cardiovascular effects of gliptins[J].Nat Rev Cardiol,2013,10(2):73-84.
  • 6Mc Adam-Marx C,Mukherjee J,Bellows BK,et al.Evaluation of the relationship between weight change and glycemic control after initiation of antidiabetic therapy in patients with type 2 diabetes using electronic medical record data[J].Diabetes Res Clin Pract,2014,103(3):402-411.
  • 7Karagiannis T,Paschos P,Paletas K,et al.Dipeptidyl peptidase-4inhibitors for treatment of type 2 diabetes mellitus in the clinical setting:systematic review and meta-analysis[J].BMJ,2012,344:e1369.
  • 8Kato H,Nagai Y,Ohta A,et al.Effect of sitagliptin on intrahepatic lipid content and body fat in patients with type 2 diabetes[J].Diabetes Res Clin Pract,2015,109(1):199-205.
  • 9Zaruba MM,Theiss HD,Vallaster M,et al.Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction[J].Cell Stem Cell,2009,4(4):313-323.
  • 10Drucker DJ.Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes preclinical biology and mechanisms of action[J].Diabetes Care,2007,30(6):1335-1343.

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