帕金森病冲动控制障碍的危险因素及影像学研究进展

Impulse control disorders in Parkinson′s disease:risk factors and imaging studies

冲动控制障碍是帕金森病患者常见的非运动症状,严重影响患者及照料者的生活质量。但其致病机制尚不清楚,其发生与多种危险因素有关,包括多巴胺替代治疗、情绪障碍、性别、遗传因素等。研究发现,冲动控制障碍涉及中脑皮质边缘系统多个部位的改变。现对帕金森病伴冲动控制障碍的危险因素、影像学研究进行综述,以提高帕金森病伴冲动控制障碍的早期诊断水平。

Impulse control disorders,a common non-motor symptom in Parkinson′s disease(PD)patients,can have an exceedingly grave impact on the quality of life for the affected PD patients,as well as their families and caretakers.The mechanisms of impulse control disorders in PD are still unknown,and the prevalence of impulse control disorders depends on many factors,such as dopamine replacement therapy,mood disorders,gender and genetic factors.Several studies suggest that impulse control disorders in PD affect many regions of the mesocorticolimbic circuit.This article will give a comprehensive overview of the progress in the risk factors and imaging study of impulse control disorders in PD,which is helpful to the early diagnosis of this disease.