精神分裂症患者血清炎症因子变化与临床症状及认知功能的相关性

Correlation of serum inflammatory factors with clinical symptoms and cognitive functions in schizophrenia

目的研究精神分裂症患者血清炎症因子水平变化及其与临床症状和认知功能之间的关系。方法纳入精神分裂症患者42例(病例组),健康对照47例(对照组),采用酶联免疫吸附技术(ELISA)测定所有受试者血清中6种炎症因子浓度,应用阳性和阴性症状量表(PANSS)评估临床症状,应用精神分裂症认知功能成套测验共识版(MCCB)评估认知功能。结果炎症因子:病例组IL-1β、IL-4、IL-6及IL-8水平明显高于对照组(P<0.01)。认知功能:病例组在线测验、霍普金斯词语学习、符号编码、空间广度、视觉空间记忆测验、迷宫测验、语义流畅性及情绪管理测验的评分均明显低于对照组(P<0.05)。炎症因子水平与临床症状的相关性:未发现精神分裂症患者血清炎症因子与精神症状相关。炎症因子水平与认知功能的相关性:病例组血清中IL-6(rs=-0.33,P<0.05)、IL-8(rs=-0.50,P<0.01)水平与空间广度测验的评分呈负相关。结论精神分裂症患者同时存在免疫功能异常和认知功能损害,认知功能的损害与这种免疫功能的异常相关。

Objective To study the correlation of clinical symptoms and cognitive functions with serum inflammatory factors in schizophrenia. Methods A total of 42 SCz patients(case group) and 47 healthy controls(control group) were enrolled in this study. We used enzyme-linked immunosorbent assay(ELSA) to determine six inflammatory factors in serum. PANSS was used to assess clinical symptoms and MCCB was used to assess the patients’ cognitive functions. Results(1) Inflammatory factors: The serum levels of IL-1β, IL-4, IL-6 and IL-8 were significantly higher in case group than in control group(P<0.01).(2) Cognitive functions: The scores of Trail Making Test, Hopkins Verbal Learning Test, Symbol Coding, Spatial Span, Brief Visuospatial Memory Test, Assessment Battery-Mazes, Category Fluency and Test-Managing Emotions of case group were significantly lower than those of control group(P<0.05).(3) Correlation between serum inflammatory factors and clinical symptoms: There was no correlation between serum inflammatory factors and psychiatric symptoms in schizophrenia.(4) Correlation between serum inflammatory factors and cognitive functions: The levels of IL-6(rs=-0.33, P<0.05) and IL-8(rs=-0.50, P<0.01) in case group were significantly negatively correlated with the scores of Space Scan test.Conclusion Patients with schizophrenia are presented with immune dysfunction,and the latter is correlated with cognitive impairments.