摘要
目的探讨宁泌泰胶囊联合萘哌地尔治疗慢性非细菌性前列腺炎的疗效观察。方法选取2017年5月—2019年5月在河南大学淮河医院泌尿科住院治疗的106例慢性非细菌性前列腺炎患者为研究对象,按照随机数字表法分成对照组和治疗组,每组各有53例。对照组患者口服萘哌地尔分散片,起始剂量为25mg/次,1次/d,1周后未到理想疗效,可增加到50mg/次,1次/d,饭后服用。治疗组在对照组基础上口服宁泌泰胶囊,3~4粒/次,3次/d,饭后服用。两组患者均连续治疗7 d。观察两组的临床疗效,比较两组临床症状的消失时间;同时比较两组最大尿流率、平均尿流率、前列腺液中炎性因子的变化情况。结果治疗后,治疗组总有效率96.23%,显著高于对照组的83.02%(P<0.05)。治疗后,治疗组患者尿频消退时间、尿急消退时间、排尿困难消退时间均显著短于对照组(P<0.05)。治疗后,两组患者最大尿流率、平均尿流率均较治疗前显著提高(P<0.05);且治疗后,治疗组最大尿流率、平均尿流率显著高于对照组(P<0.05)。治疗后,两组患者前列腺液中炎性因子白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、肿瘤坏死因子α(TNF-α)水平均较治疗前显著降低(P<0.05);治疗后,治疗组前列腺液中炎性因子水平显著对于对照组(P<0.05)。结论宁泌泰胶囊联合萘哌地尔治疗慢性非细菌性前列腺炎具有较好的临床疗效,能有效改善前列腺局部炎症反应,减低局部炎性细胞因子水平,在临床上具有一定的参考价值。
Objective To investigate the curative effect of Ningmitai Capsules combined with naftopidil in treatment of chronic nonbacterial prostatitis. Methods A total of 106 patients with chronic non-bacterial prostatitis who were hospitalized in the Department of Urology of Huaihe Hospital of Henan University from May 2017 to May 2019 were selected as the research subjects. According to the random number table method, they were divided into control group and treatment group, with 53 patients in each group. Patients in the control group were po administered with Naftopidil Dispersible Tablets after meals, and the initial dosage was 25 mg/time, once daily. If the effect was not satisfactory after 1 week, the dosage could be increased to 50 mg/time, once daily. Patients in the treatment group were po administered with Ningmitai Capsules after meals on the basis of the control group, 3 — 4 grains/time, three times daily. Patients in both groups were treated continuously for 7 d. The clinical efficacy of the two groups was observed, and the disappearance time of clinical symptoms was compared between the two groups. The maximum urinary flow rate, mean urinary flow rate and inflammatory factors in prostatic fluid were compared between the two groups. Results After treatment, the total effective rate of treatment group was 96.23%, which was significantly higher than that of control group(83.02%, P < 0.05). After treatment, the subsidence time of frequency, urgency and dysuria in the treatment group was significantly shorte r than that in the control group(P < 0.05). After treatment, the maximum and average urinary flow rate in two groups were significantly increased compared with before treatment(P < 0.05);After treatment, the maximum and average urinary flow rate in treatment group were significantly higher than those in control group(P < 0.05). After treatment, the levels of IL-2, IL-6, IL-1β, and TNF-α in prostatic fluid of two groups were significantly decreased compared with before treatment(P < 0.05). After treatment, the level of inflammatory factors in prostatic fluid in treatment group was significantly higher than that in control group(P < 0.05). Conclusion Ningmitai Capsules combined with naftopidil has a good clinical effect in treatment of chronic non-bacterial prostatitis, and can effectively improve the local inflammatory response of the prostate, reduce the level of local inflammatory cytokines, which has a certain reference value in clinical practice.
作者
徐卫波
侯俊清
徐文超
朱朝阳
刘辉
XU Wei-bo;HOU Jun-qing;XU Wen-chao;ZHU Chao-yang;LIU Hui(Department of Urology,Huaihe Hospital of Henan University,Kaifeng 475000,China)
出处
《现代药物与临床》
CAS
2021年第1期121-125,共5页
Drugs & Clinic
基金
河南省科技发展计划项目(192102310109)。